COMMD1 antibody (AA 1-190)

Catalog No. ABIN566862

Product Details anti-COMMD1 Antibody

Target: COMMD1 (Copper Metabolism (Murr1) Domain Containing 1 (COMMD1))

Binding Specificity: AA 1-190

Reactivity: Human

Host: Mouse

Clonality: Monoclonal

Conjugate: This COMMD1 antibody is un-conjugated

Application: Western Blotting (WB), ELISA, Immunoprecipitation (IP)

Purpose: Mouse monoclonal antibody raised against a full length recombinant COMMD1.

Sequence: MAAGELEGGK PLSGLLNALA QDTFHGYPGI TEELLRSQLY PEVPPEEFRP FLAKMRGILK SIASADMDFN QLEAFLTAQT KKQGGITSDQ AAVISKFWKS HKTKIRESLM NQSRWNSGLR GLSWRVDGKS QSRHSAQIHT PVAIIELELG KYGQESEFLC LEFDEVKVNQ ILKTLSEVEE SISTLISQPN

Cross-Reactivity: Human

Characteristics: Antibody Reactive Against Recombinant Protein.

Immunogen: COMMD1 (AAH22046.1, 1 a.a. ~ 190 a.a) full-length recombinant protein with GST tag. MW of the GST tag alone is 26 KDa.

Clone: 2A12

Isotype: IgG2a

Application Details

Application Notes: Optimal working dilution should be determined by the investigator.

Restrictions: For Research Use only

Handling

Buffer: In 1x PBS, pH 7.4

Handling Advice: Aliquot to avoid repeated freezing and thawing.

Storage: -20 °C

Storage Comment: Store at -20°C or lower. Aliquot to avoid repeated freezing and thawing.

References for anti-COMMD1 antibody (ABIN566862)

OHara, Simpson, Morin, Loveridge, Williams, Novo, Stark: "p300-mediated acetylation of COMMD1 regulates its stability, and the ubiquitylation and nucleolar translocation of the RelA NF-?B subunit." in: Journal of cell science, Vol. 127, Issue Pt 17, pp. 3659-65, (2014) (PubMed).

Schilling, Bayer, Li, Molls, Vaupel, Multhoff: "Radiosensitization of normoxic and hypoxic h1339 lung tumor cells by heat shock protein 90 inhibition is independent of hypoxia inducible factor-1?." in: PLoS ONE, Vol. 7, Issue 2, pp. e31110, (2012) (PubMed).

Drévillon, Tanguy, Hinzpeter, Arous, de Becdelièvre, Aissat, Tarze, Goossens, Fanen: "COMMD1-mediated ubiquitination regulates CFTR trafficking." in: PLoS ONE, Vol. 6, Issue 3, pp. e18334, (2011) (PubMed).

Vonk, Wijmenga, Berger, van de Sluis, Klomp: "Cu,Zn superoxide dismutase maturation and activity are regulated by COMMD1." in: The Journal of biological chemistry, Vol. 285, Issue 37, pp. 28991-9000, (2010) (PubMed).

Huang, Wu, Li: "Tumor suppressor ARF promotes non-classic proteasome-independent polyubiquitination of COMMD1." in: The Journal of biological chemistry, Vol. 283, Issue 17, pp. 11453-60, (2008) (PubMed).

Burkhead, Morgan, Shinde, Haddock, Lutsenko: "COMMD1 forms oligomeric complexes targeted to the endocytic membranes via specific interactions with phosphatidylinositol 4,5-bisphosphate." in: The Journal of biological chemistry, Vol. 284, Issue 1, pp. 696-707, (2008) (PubMed).

Weiss, Lozoya, Tuma, Gotthardt, Reichert, Ehehalt, Stremmel, Füllekrug: "Copper-induced translocation of the Wilson disease protein ATP7B independent of Murr1/COMMD1 and Rab7." in: The American journal of pathology, Vol. 173, Issue 6, pp. 1783-94, (2008) (PubMed).

Maine, Mao, Komarck, Burstein: "COMMD1 promotes the ubiquitination of NF-kappaB subunits through a cullin-containing ubiquitin ligase." in: The EMBO journal, Vol. 26, Issue 2, pp. 436-47, (2007) (PubMed).

de Bie, van de Sluis, Burstein, van de Berghe, Muller, Berger, Gitlin, Wijmenga, Klomp: "Distinct Wilson's disease mutations in ATP7B are associated with enhanced binding to COMMD1 and reduced stability of ATP7B." in: Gastroenterology, Vol. 133, Issue 4, pp. 1316-26, (2007) (PubMed).

Target Details for COMMD1

Target: COMMD1 (Copper Metabolism (Murr1) Domain Containing 1 (COMMD1))

Alternative Name: COMMD1 (COMMD1 Products)

Synonyms: C2orf5 antibody, MURR1 antibody, murr1 antibody, commd1 antibody, si:ch211-213b8.2 antibody, DDBDRAFT_0184206 antibody, DDBDRAFT_0266452 antibody, DDB_0184206 antibody, DDB_0266452 antibody, COMMD1 antibody, MGC114682 antibody, AI256843 antibody, Murr1 antibody, U2/Mu antibody, copper metabolism domain containing 1 antibody, copper metabolism (Murr1) domain containing 1 antibody, COMM domain-containing protein 1 antibody, copper metabolism domain containing 1 L homeolog antibody, COMM domain containing 1 antibody, COMMD1 antibody, commd1 antibody, comd1 antibody, Commd1 antibody, commd1.L antibody

Background: Full Gene Name: copper metabolism (Murr1) domain containing 1
Synonyms: C2orf5,MGC27155,MURR1

Gene ID: 150684

Pathways: Transition Metal Ion Homeostasis