Recombinant IL-6R (Tocilizumab Biosimilar) antibody
(1 reference)-
- Target See all IL-6R (Tocilizumab Biosimilar) products
- IL-6R (Tocilizumab Biosimilar)
- Antibody Type
- Recombinant Antibody
- Reactivity
- Human
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Host
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Human
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Clonality
- Monoclonal
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Conjugate
- This IL-6R (Tocilizumab Biosimilar) antibody is un-conjugated
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Application
- ELISA, Inhibition Assay (InhA)
- Specificity
- Tocilizumab binds specifically to both the membrane bound and soluble forms of human IL-6R. The IL6 receptor is a protein complex consisting of an IL-6 receptor subunit (IL6R) and interleukin 6 signal transducer Glycoprotein 130. Interleukin 6 (IL6) is a potent pleiotropic cytokine that regulates cell growth and differentiation and plays an important role in immune response.
- Characteristics
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OriginalSpeciesName: Human
OriginalFormat: IgG1
- Purification
- Purified antibody.
- Purity
- > 98 % as determined by SDS-PAGE
- Endotoxin Level
- Endotoxin is < 1.0 EU/mg as determined by the LAL method
- Immunogen
- This antibody was prepared by CDR grafting of mouse AUK 12-20 antibody onto a human framework regions.
- Clone
- RhPM-1
- Isotype
- IgG1 kappa
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anti-IL-6R (Tocilizumab Biosimilar) antibody
Research Grade Reactivity: Human ELISA, FACS Host: Humanized Monoclonal unconjugated Recombinant Antibody
anti-IL-6R (Tocilizumab Biosimilar) antibodyReactivity: Human ELISA, InhA Host: Rabbit Monoclonal RhPM-1 unconjugated Recombinant Antibody
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- Application Notes
- Tocilizumab can be used in ELISA assays and is able to inhibit the growth of IL-6-dependent tumor cell lines (to the same extent as the original AUK12-20 mouse antibody) - inhibits sIL-6R and mIL-6R-mediated signaling.
- Comment
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NOT FOR THERAPEUTIC USE - This is a research-grade biosimilar.
- Restrictions
- For Research Use only
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- Buffer
- PBS with 0.02 % Proclin 300.
- Preservative
- ProClin
- Precaution of Use
- This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
- Storage
- 4 °C,-20 °C
- Storage Comment
- Store at 4°C for up to 3 months. For longer storage, aliquot and store at -20°C.
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-
: "IL-6 receptor blockade corrects defects of XIAP-deficient regulatory T cells." in: Nature communications, Vol. 9, Issue 1, pp. 463, (2018) (PubMed).
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: "IL-6 receptor blockade corrects defects of XIAP-deficient regulatory T cells." in: Nature communications, Vol. 9, Issue 1, pp. 463, (2018) (PubMed).
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- Target
- IL-6R (Tocilizumab Biosimilar)
- Abstract
- IL-6R (Tocilizumab Biosimilar) Products
- Synonyms
- CD126 antibody, IL-6R-1 antibody, IL-6RA antibody, IL6Q antibody, IL6RA antibody, IL6RQ antibody, gp80 antibody, interleukin 6 receptor antibody, IL6R antibody
- Target Type
- Biosimilar
- Background
- IL6R, MRA, atlizumab
- UniProt
- A0N0L5
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