Phone:
+1 877 302 8632
Fax:
+1 888 205 9894 (Toll-free)
E-Mail:
orders@antibodies-online.com

Recombinant ErbB2/Her2 (Trastuzumab Biosimilar) antibody

Reactivity: Human FACS, ELISA, IHC Host: Human Monoclonal 4D5-8 unconjugated Recombinant Antibody
Catalog No. ABIN5668226
  • Target See all ErbB2/Her2 (Trastuzumab Biosimilar) products
    ErbB2/Her2 (Trastuzumab Biosimilar)
    Antibody Type
    Recombinant Antibody
    Reactivity
    Human
    Host
    • 1
    • 1
    • 1
    • 1
    Human
    Clonality
    • 4
    Monoclonal
    Conjugate
    • 4
    This ErbB2/Her2 (Trastuzumab Biosimilar) antibody is un-conjugated
    Application
    • 3
    • 2
    • 1
    • 1
    Flow Cytometry (FACS), ELISA, Immunohistochemistry (IHC)
    Specificity
    Oncogenic protein Her-2/neu (erbB-2), a member of the family of epidermal growth factor (EGF) receptors, overexpressed in 30 % of invasive breast cancers and 70 % of ductal carcinomata in situ, in a small percentage of melanomas, and in other malignancies originating from various organs, including ovary, kidney, colon, and bladder.
    Characteristics

    OriginalSpeciesName: Human

    OriginalFormat: IgG1

    Purification
    Purified antibody.
    Purity
    > 98 % as determined by SDS-PAGE
    Endotoxin Level
    Endotoxin is < 1.0 EU/mg as determined by the LAL method
    Immunogen
    A431 cells (human epidermoid carcinoma) (over)expressing EGFR.
    Clone
    4D5-8
    Isotype
    IgG1 kappa
  • Application Notes
    Optimal working dilution should be determined by the investigator.
    Comment

    NOT FOR THERAPEUTIC USE - This is a research-grade biosimilar.

    Restrictions
    For Research Use only
  • Buffer
    PBS with 0.02 % Proclin 300.
    Preservative
    ProClin
    Precaution of Use
    This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
    Storage
    4 °C,-20 °C
    Storage Comment
    Store at 4°C for up to 3 months. For longer storage, aliquot and store at -20°C.
  • Maisel, Broka, Atwell, Bunch, Kupp, Singh, Mehta, Schroeder: "Stapled EGFR peptide reduces inflammatory breast cancer and inhibits additional HER-driven models of cancer." in: Journal of translational medicine, Vol. 17, Issue 1, pp. 201, (2020) (PubMed).

  • Target
    ErbB2/Her2 (Trastuzumab Biosimilar)
    Abstract
    ErbB2/Her2 (Trastuzumab Biosimilar) Products
    Synonyms
    CD340 antibody, HER-2 antibody, HER-2/neu antibody, HER2 antibody, MLN 19 antibody, NEU antibody, NGL antibody, TKR1 antibody, erb-b2 receptor tyrosine kinase 2 antibody, ERBB2 antibody
    Target Type
    Biosimilar
    Background
    CD340, Metastatic lymph node gene 19 protein (MLN 19), Proto-oncogene Neu, Proto-oncogene c-ErbB-2, Tyrosine kinase-type cell surface receptor HER2, p185erbB2, p185HER2, EGFR
    UniProt
    P04626
You are here:
Support