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Recombinant CD33 (Gemtuzumab Biosimilar) antibody

Reactivity: Human FACS, IF Host: Rabbit Monoclonal HP67-6 unconjugated Recombinant Antibody
Catalog No. ABIN5668211
  • Target See all CD33 (Gemtuzumab Biosimilar) products
    CD33 (Gemtuzumab Biosimilar)
    Antibody Type
    Recombinant Antibody
    Reactivity
    Human
    Host
    • 1
    • 1
    • 1
    Rabbit
    Clonality
    • 3
    Monoclonal
    Conjugate
    • 3
    This CD33 (Gemtuzumab Biosimilar) antibody is un-conjugated
    Application
    • 2
    • 1
    • 1
    Flow Cytometry (FACS), Immunofluorescence (IF)
    Specificity
    Recognises human CD33.
    Characteristics

    OriginalSpeciesName: Human

    OriginalFormat: IgG4

    Purification
    Purified antibody.
    Purity
    > 98 % as determined by SDS-PAGE
    Endotoxin Level
    Endotoxin is < 1.0 EU/mg as determined by the LAL method
    Immunogen
    Gemtuzumab was generated by huminization of the murine P67.6 clone, raised against CD33-transfected FMY9S5 cells of human origin. CD33 is a transmembrane receptor expressed on predominantly on cells of the myeloid lineage, but it can also be found on some lymphoid cells.
    Clone
    HP67-6
    Isotype
    IgG kappa
  • Application Notes
    A human IgG4 variant conjugated to derivative of the cytotoxic drug calicheamicin gamma 1, N-acetylcalicheamicin dimethyl hydrazide, has been used as a therapeutic against acute myeloid leukemia. This antibody may also be used in flow cytometry and immunofluorescence.
    Comment

    This chimeric rabbit antibody was made using the variable domain sequences of the original Human IgG4 format, for improved compatibility with existing reagents, assays and techniques.

    Restrictions
    For Research Use only
  • Buffer
    PBS with 0.02 % Proclin 300.
    Preservative
    ProClin
    Precaution of Use
    This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
    Storage
    4 °C,-20 °C
    Storage Comment
    Store at 4°C for up to 3 months. For longer storage, aliquot and store at -20°C.
  • Target
    CD33 (Gemtuzumab Biosimilar)
    Abstract
    CD33 (Gemtuzumab Biosimilar) Products
    Synonyms
    SIGLEC-3 antibody, SIGLEC3 antibody, p67 antibody, CD33 molecule antibody, CD33 antibody
    Target Type
    Biosimilar
    Background
    Siglec-3
    UniProt
    P20138
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