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Recombinant RSV (Felvizumab Biosimilar) antibody

Reactivity: Respiratory Syncytial Virus (RSV) ELISA, Func Host: Rabbit Monoclonal RSHZ19 unconjugated Recombinant Antibody
Catalog No. ABIN5668207
  • Target See all RSV (Felvizumab Biosimilar) products
    RSV (Felvizumab Biosimilar)
    Antibody Type
    Recombinant Antibody
    Reactivity
    Respiratory Syncytial Virus (RSV)
    Host
    • 1
    Rabbit
    Clonality
    • 1
    Monoclonal
    Conjugate
    • 1
    This RSV (Felvizumab Biosimilar) antibody is un-conjugated
    Application
    ELISA, Functional Studies (Func)
    Specificity
    This antibody is specific for the conserved fusion (F) protein of RSV.
    Characteristics

    OriginalSpeciesName: Human

    OriginalFormat: IgG1

    Purification
    Purified antibody.
    Purity
    > 98 % as determined by SDS-PAGE
    Endotoxin Level
    Endotoxin is < 1.0 EU/mg as determined by the LAL method
    Immunogen
    This antibody was prepared by the humanization of an F protein-specific murine MAb, RSV19. More specifically, molecular techniques were used to insert the complementarity determining regions from murine RSV19 into a human IgG1 heavy and k light chain-variable domain framework.
    Clone
    RSHZ19
    Isotype
    IgG kappa
  • Application Notes
    Though shown to be safe and well-tolerated (Everitt, 1996) and protective against RSV infection in BALB/c mice and cotton rats (Wyde, 1995), this antibody did not demonstrate efficacy in a Phase 3 study (Reichert, 2008). In in vitro studies, palivizumab, another humanized Mab specific for the F protein of RSV, was 4 to 5-fold more potent than felvizumab in neutralising RSV (Scott, 1999).
    Comment

    This chimeric rabbit antibody was made using the variable domain sequences of the original Human IgG1 format, for improved compatibility with existing reagents, assays and techniques.

    Restrictions
    For Research Use only
  • Buffer
    PBS with 0.02 % Proclin 300.
    Preservative
    ProClin
    Precaution of Use
    This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
    Storage
    4 °C,-20 °C
    Storage Comment
    Store at 4°C for up to 3 months. For longer storage, aliquot and store at -20°C.
  • Target
    RSV (Felvizumab Biosimilar)
    Abstract
    RSV (Felvizumab Biosimilar) Products
    Target Type
    Biosimilar
    Background
    SB 209763, respiratory syncytial virus
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