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Recombinant RSV (Felvizumab Biosimilar) antibody

Reactivity: Respiratory Syncytial Virus (RSV) ELISA, Func Host: Human Monoclonal RSHZ19 unconjugated Recombinant Antibody
Catalog No. ABIN5668206
  • Target See all RSV (Felvizumab Biosimilar) products
    RSV (Felvizumab Biosimilar)
    Antibody Type
    Recombinant Antibody
    Reactivity
    Respiratory Syncytial Virus (RSV)
    Host
    • 1
    Human
    Clonality
    • 1
    Monoclonal
    Conjugate
    • 1
    This RSV (Felvizumab Biosimilar) antibody is un-conjugated
    Application
    ELISA, Functional Studies (Func)
    Specificity
    This antibody is specific for the conserved fusion (F) protein of RSV.
    Characteristics

    OriginalSpeciesName: Human

    OriginalFormat: IgG1

    Purification
    Purified antibody.
    Purity
    > 98 % as determined by SDS-PAGE
    Endotoxin Level
    Endotoxin is < 1.0 EU/mg as determined by the LAL method
    Immunogen
    This antibody was prepared by the humanization of an F protein-specific murine MAb, RSV19. More specifically, molecular techniques were used to insert the complementarity determining regions from murine RSV19 into a human IgG1 heavy and k light chain-variable domain framework.
    Clone
    RSHZ19
    Isotype
    IgG1 kappa
  • Application Notes
    Though shown to be safe and well-tolerated (Everitt, 1996) and protective against RSV infection in BALB/c mice and cotton rats (Wyde, 1995), this antibody did not demonstrate efficacy in a Phase 3 study (Reichert, 2008). In in vitro studies, palivizumab, another humanized Mab specific for the F protein of RSV, was 4 to 5-fold more potent than felvizumab in neutralising RSV (Scott, 1999).
    Restrictions
    For Research Use only
  • Buffer
    PBS with 0.02 % Proclin 300.
    Preservative
    ProClin
    Precaution of Use
    This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
    Storage
    4 °C,-20 °C
    Storage Comment
    Store at 4°C for up to 3 months. For longer storage, aliquot and store at -20°C.
  • Target
    RSV (Felvizumab Biosimilar)
    Abstract
    RSV (Felvizumab Biosimilar) Products
    Target Type
    Biosimilar
    Background
    SB 209763, respiratory syncytial virus
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