Recombinant ITGA4 (Natalizumab Biosimilar) antibody
(1 reference)-
- Target See all ITGA4 (Natalizumab Biosimilar) products
- ITGA4 (Natalizumab Biosimilar)
- Antibody Type
- Recombinant Antibody
- Reactivity
- Human
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Host
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Human
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Clonality
- Monoclonal
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Conjugate
- This ITGA4 (Natalizumab Biosimilar) antibody is un-conjugated
- Application
- Flow Cytometry (FACS), Blocking Reagent (BR)
- Specificity
- This antibody binds to the alpha 4 binds subunit of α4β1 (also known as very late antigen 4 [VLA-4] or CD49d-CD29) and α4β7 integrin
- Characteristics
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OriginalSpeciesName: Human
OriginalFormat: IgG4
- Purification
- Purified antibody.
- Purity
- > 98 % as determined by SDS-PAGE
- Endotoxin Level
- Endotoxin is < 1.0 EU/mg as determined by the LAL method
- Immunogen
- The RAMOS cell line, a non-EBV releasing cell line, injected into mice.
- Isotype
- IgG4 kappa
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anti-ITGA4 (Natalizumab Biosimilar) antibody
Research Grade Reactivity: Human FACS Host: Humanized Monoclonal unconjugated Recombinant Antibody
anti-ITGA4 (Natalizumab Biosimilar) antibodyReactivity: Human FACS, BR Host: Rabbit Chimeric unconjugated Recombinant Antibody
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- Application Notes
- This antibody binds to human integrin alpha 4 and has been used to treat Multiple Sclerosis and Crohn's Disease.
- Comment
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NOT FOR THERAPEUTIC USE - This is a research-grade biosimilar.
- Restrictions
- For Research Use only
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- Buffer
- PBS with 0.02 % Proclin 300.
- Preservative
- ProClin
- Precaution of Use
- This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
- Storage
- 4 °C,-20 °C
- Storage Comment
- Store at 4°C for up to 3 months. For longer storage, aliquot and store at -20°C.
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-
: "An innovative strategy to identify new targets for delivering antibodies to the brain has led to the exploration of the integrin family." in: PloS one, Vol. 17, Issue 9, pp. e0274667, (2022) (PubMed).
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: "An innovative strategy to identify new targets for delivering antibodies to the brain has led to the exploration of the integrin family." in: PloS one, Vol. 17, Issue 9, pp. e0274667, (2022) (PubMed).
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- Target
- ITGA4 (Natalizumab Biosimilar)
- Abstract
- ITGA4 (Natalizumab Biosimilar) Products
- Synonyms
- CD49D antibody, IA4 antibody, integrin subunit alpha 4 antibody, ITGA4 antibody
- Background
- CD49D, alpha 4 subunit of VLA-4 receptor, ITGA4, Integrin alpha-IV
- UniProt
- P13612
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