Recombinant TNF alpha (Infliximab Biosimilar) antibody
Reactivity: Human
FACS, in vivo, ELISA
Host: Human
Chimeric
cA2
unconjugated
Recombinant Antibody
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- Target See all TNF alpha (Infliximab Biosimilar) products
- TNF alpha (Infliximab Biosimilar)
- Antibody Type
- Recombinant Antibody
- Reactivity
- Human
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Host
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Human
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Clonality
- Chimeric
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Conjugate
- This TNF alpha (Infliximab Biosimilar) antibody is un-conjugated
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Application
- Flow Cytometry (FACS), In vivo Studies (in vivo), ELISA
- Purpose
- Anti-TNF alpha [cA2 (Infliximab)], Human IgG1, kappa
- Specificity
- Binds to soluble and transmembrane forms of TNF-alpha and neutralizes its biological activity. Does not bind to TNF-beta.
- Characteristics
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Original Species of Ab: Human
Original Format of Ab: IgG1
- Purification
- Protein A affinity purified
- Purity
- > 98 % as determined by SDS-PAGE
- Endotoxin Level
- Endotoxin is < 1.0 EU/mg as determined by the LAL method
- Immunogen
- Purified recombinant human TNF (rTNF).
- Clone
- CA2
- Isotype
- IgG1 kappa
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- Application Notes
- This antibody can be used to detect and neutralize human TNF alpha. Unlike Adalimumab (Ab00718), Infliximab does not bind to mouse TNF alpha (Arnoult 2017, PMID: 28584008).
- Comment
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NOT FOR THERAPEUTIC USE - This is a research-grade biosimilar. This is a chimeric antibody created for improved compatibility with existing reagents, assays and techniques.
- Restrictions
- For Research Use only
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- Concentration
- 1 mg/mL
- Buffer
- PBS with 0.02 % Proclin 300.
- Preservative
- ProClin
- Precaution of Use
- This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
- Storage
- 4 °C,-20 °C
- Storage Comment
- Store at 4°C for up to 3 months. For longer storage, aliquot and store at -20°C.
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- Target
- TNF alpha (Infliximab Biosimilar)
- Abstract
- TNF alpha (Infliximab Biosimilar) Products
- Target Type
- Biosimilar
- Background
- TNF-α, TNFα, TNFSF, Tumor necrosis factor, Cachectin, TNF-alpha, Tumor necrosis factor ligand superfamily member 2, TNF-a, TNFa
- UniProt
- P01375
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