Recombinant TNF alpha (Adalimumab Biosimilar) antibody
Reactivity: Human
ELISA, BR, IF, IHC
Host: Rabbit
Monoclonal
D2E7
unconjugated
Recombinant Antibody
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- Target See all TNF alpha (Adalimumab Biosimilar) products
- TNF alpha (Adalimumab Biosimilar)
- Antibody Type
- Recombinant Antibody
- Reactivity
- Human
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Host
- Rabbit
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Clonality
- Monoclonal
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Conjugate
- This TNF alpha (Adalimumab Biosimilar) antibody is un-conjugated
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Application
- ELISA, Blocking Reagent (BR), Immunofluorescence (IF), Immunohistochemistry (IHC)
- Specificity
- Binds to soluble TNF-alpha, but not to lymphotoxin (TNF beta).
- Characteristics
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OriginalSpeciesName: Human
OriginalFormat: IgG1
- Purification
- Purified antibody.
- Purity
- > 98 % as determined by SDS-PAGE
- Endotoxin Level
- Endotoxin is < 1.0 EU/mg as determined by the LAL method
- Immunogen
- This antibody was generated by affinity maturation from the 2SD4 scFv, which in turn was selected on human TNF alpha by guided phage-display technology, using the murine anti-hTNF alpha antibody Mab32 as a template (c.f. also US Patent 6090382).
- Clone
- D2E7
- Isotype
- IgG kappa
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anti-TNF alpha (Adalimumab Biosimilar) antibody
Research Grade Reactivity: Human FACS, ELISA Host: Human Monoclonal unconjugated Recombinant Antibody
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- Application Notes
- Adalimumab binds specifically to TNF and neutralizes the biological function of TNF by blocking its interaction with the p55 and p75 cell surface TNF receptors.
- Comment
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NOT FOR THERAPEUTIC USE - This is a research-grade biosimilar. This chimeric rabbit antibody was made using the variable domain sequences of the original human IgG1 format, for improved compatibility with existing reagents, assays and techniques.
- Restrictions
- For Research Use only
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- Buffer
- PBS with 0.02 % Proclin 300.
- Preservative
- ProClin
- Precaution of Use
- This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
- Storage
- 4 °C,-20 °C
- Storage Comment
- Store at 4°C for up to 3 months. For longer storage, aliquot and store at -20°C.
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- Target
- TNF alpha (Adalimumab Biosimilar)
- Abstract
- TNF alpha (Adalimumab Biosimilar) Products
- Synonyms
- DIF antibody, TNF-alpha antibody, TNFA antibody, TNFSF2 antibody, tumor necrosis factor antibody, TNF antibody
- Target Type
- Biosimilar
- Background
- Tumor necrosis factor alpha
- UniProt
- P01375
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