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Recombinant TNF alpha (Adalimumab Biosimilar) antibody

Reactivity: Human ELISA, BR, IF, IHC Host: Human Monoclonal D2E7 unconjugated Recombinant Antibody
Catalog No. ABIN5668145
  • Target See all TNF alpha (Adalimumab Biosimilar) products
    TNF alpha (Adalimumab Biosimilar)
    Antibody Type
    Recombinant Antibody
    Reactivity
    Human
    Host
    • 1
    • 1
    • 1
    • 1
    Human
    Clonality
    • 4
    Monoclonal
    Conjugate
    • 4
    This TNF alpha (Adalimumab Biosimilar) antibody is un-conjugated
    Application
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    ELISA, Blocking Reagent (BR), Immunofluorescence (IF), Immunohistochemistry (IHC)
    Specificity
    Binds to soluble TNF-alpha, but not to lymphotoxin (TNF beta).
    Characteristics

    OriginalSpeciesName: Human

    OriginalFormat: IgG1

    Purification
    Purified antibody.
    Purity
    > 98 % as determined by SDS-PAGE
    Endotoxin Level
    Endotoxin is < 1.0 EU/mg as determined by the LAL method
    Immunogen
    This antibody was generated by affinity maturation from the 2SD4 scFv, which in turn was selected on human TNF alpha by guided phage-display technology, using the murine anti-hTNF alpha antibody Mab32 as a template (c.f. also US Patent 6090382).
    Clone
    D2E7
    Isotype
    IgG1 kappa
  • Application Notes
    Adalimumab binds specifically to TNF and neutralizes the biological function of TNF by blocking its interaction with the p55 and p75 cell surface TNF receptors.
    Comment

    NOT FOR THERAPEUTIC USE - This is a research-grade biosimilar.

    Restrictions
    For Research Use only
  • Buffer
    PBS with 0.02 % Proclin 300.
    Preservative
    ProClin
    Precaution of Use
    This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
    Storage
    4 °C,-20 °C
    Storage Comment
    Store at 4°C for up to 3 months. For longer storage, aliquot and store at -20°C.
  • Gupta, Flaskamp, Roentgen, Juergens, Armero-Gimenez, Albrecht, Hemmerich, Arfi, Neuser, Spiegel, Schillberg, Yeliseev, Song, Qiu, Williams, Finnern: "Scaling eukaryotic cell-free protein synthesis achieved with the versatile and high-yielding tobacco BY-2 cell lysate." in: Biotechnology and bioengineering, (2023) (PubMed).

  • Target
    TNF alpha (Adalimumab Biosimilar)
    Abstract
    TNF alpha (Adalimumab Biosimilar) Products
    Synonyms
    DIF antibody, TNF-alpha antibody, TNFA antibody, TNFSF2 antibody, tumor necrosis factor antibody, TNF antibody
    Target Type
    Biosimilar
    Background
    Tumor necrosis factor alpha
    UniProt
    P01375
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