Recombinant TNF alpha (Humicade Biosimilar) antibody
Reactivity: Human
ELISA
Host: Human
Monoclonal
CDP 571
unconjugated
Recombinant Antibody
-
- Target
- TNF alpha (Humicade Biosimilar)
- Antibody Type
- Recombinant Antibody
- Reactivity
- Human
-
Host
-
Human
-
Clonality
- Monoclonal
-
Conjugate
- Un-conjugated
- Application
- ELISA
- Purpose
- Anti-TNF alpha [CDP 571 (Humicade)], Human IgG4, kappa
- Specificity
- The antibody binds to human TNF-alpha with a Kd of 0.087 nM.
- Characteristics
-
Original Species of Ab: Human
Original Format of Ab: IgG4
- Purification
- Protein A affinity purified
- Purity
- > 98 % as determined by SDS-PAGE
- Endotoxin Level
- Endotoxin is < 1.0 EU/mg as determined by the LAL method
- Immunogen
- Human TNF-alpha
- Clone
- CDP 571
- Isotype
- IgG4 kappa
-
-
- Application Notes
- The antibody binds specifically to TNF-alpha, a pro-inflammatory cytokine which stimulates release of other cytiokines e.g. IL-1, IL-6 and GM-CSF as well as secretion of ICAM-1 and VCAM-1 from endothelial cells. It stimulates acute phase responses and acts as a chemoattractant for NK cells and monocytes/macrophages. The antibody reached Phase II clinical trials with Celltech, UCB.
- Comment
-
NOT FOR THERAPEUTIC USE - This is a research-grade biosimilar.
- Restrictions
- For Research Use only
-
- Concentration
- 1 mg/mL
- Buffer
- PBS with 0.02 % Proclin 300.
- Preservative
- ProClin
- Precaution of Use
- This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
- Storage
- 4 °C,-20 °C
- Storage Comment
- Store at 4°C for up to 3 months. For longer storage, aliquot and store at -20°C.
-
- Target
- TNF alpha (Humicade Biosimilar)
- Target Type
- Biosimilar
- Background
- TNFA, Tumour necrosis factor superfamily member 2, TNFSF2
- UniProt
- P01375
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