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Recombinant EGFR (Matuzumab Biosimilar) antibody (Extracellular Domain)

Reactivity: Human BR, FACS, WB Host: Rabbit Chimeric unconjugated Recombinant Antibody
Catalog No. ABIN5668061
  • Target See all EGFR (Matuzumab Biosimilar) products
    EGFR (Matuzumab Biosimilar)
    Antibody Type
    Recombinant Antibody
    Binding Specificity
    Extracellular Domain
    Reactivity
    Human
    Host
    • 1
    • 1
    • 1
    Rabbit
    Clonality
    • 2
    • 1
    Chimeric
    Conjugate
    • 3
    This EGFR (Matuzumab Biosimilar) antibody is un-conjugated
    Application
    • 2
    • 2
    • 2
    • 2
    • 1
    • 1
    Blocking Reagent (BR), Flow Cytometry (FACS), Western Blotting (WB)
    Specificity
    Binds to human EGFR.
    Characteristics

    OriginalSpeciesName: Human

    OriginalFormat: IgG1

    Purification
    Purified antibody.
    Purity
    > 98 % as determined by SDS-PAGE
    Endotoxin Level
    Endotoxin is < 1.0 EU/mg as determined by the LAL method
    Immunogen
    The parental mouse antibody was generated by immunizing BALB/c mice intraperitoneally with A431 cells in phosphate buffered saline (PBS). Later on the humanzied version of the antibody was created by grafting CDRs of the murine antibody onto human constant regions.
    Isotype
    IgG kappa
  • Application Notes
    This antibody binds to human EGFR at a side distinct frm the antigen binding site, preventing conformational re-arrangement required for dimerization, a process essential for high-affinitiy ligand binding (Schmiedel 2008).
    Comment

    This chimeric rabbit antibody was made using the variable domain sequences of the original Human IgG1 format, for improved compatibility with existing reagents, assays and techniques.

    Restrictions
    For Research Use only
  • Buffer
    PBS with 0.02 % Proclin 300.
    Preservative
    ProClin
    Precaution of Use
    This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
    Storage
    4 °C,-20 °C
    Storage Comment
    Store at 4°C for up to 3 months. For longer storage, aliquot and store at -20°C.
  • Target
    EGFR (Matuzumab Biosimilar)
    Abstract
    EGFR (Matuzumab Biosimilar) Products
    Background
    ErbB-1, ERBB1, HER1, EGF, Epidermal growth factor receptor, Proto-oncogene c-ErbB-1, Receptor tyrosine-protein kinase erbB-1, EMD72000, mAb425, 425, mAb 425
    UniProt
    P00533
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