Recombinant EGFR (Matuzumab Biosimilar) antibody (Extracellular Domain)

Catalog No. ABIN5668060

Product Details anti-EGFR (Matuzumab Biosimilar) Antibody

Target: EGFR (Matuzumab Biosimilar)

Antibody Type: Recombinant Antibody

Binding Specificity: Extracellular Domain

Reactivity: Human

Host: Human

Clonality: Monoclonal

Conjugate: This EGFR (Matuzumab Biosimilar) antibody is un-conjugated

Application: Blocking Reagent (BR), Flow Cytometry (FACS), Western Blotting (WB)

Specificity: Binds to human EGFR.

Characteristics:

OriginalSpeciesName: Human

OriginalFormat: IgG1

Purification: Purified antibody.

Purity: > 98 % as determined by SDS-PAGE

Endotoxin Level: Endotoxin is < 1.0 EU/mg as determined by the LAL method

Immunogen: The parental mouse antibody was generated by immunizing BALB/c mice intraperitoneally with A431 cells in phosphate buffered saline (PBS). Later on the humanzied version of the antibody was created by grafting CDRs of the murine antibody onto human constant regions.

Isotype: IgG1 kappa

Application Details

Application Notes: This antibody binds to human EGFR at a side distinct frm the antigen binding site, preventing conformational re-arrangement required for dimerization, a process essential for high-affinitiy ligand binding (Schmiedel 2008).

Restrictions: For Research Use only

Handling

Buffer: PBS with 0.02 % Proclin 300.

Preservative: ProClin

Precaution of Use: This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: 4 °C,-20 °C

Storage Comment: Store at 4°C for up to 3 months. For longer storage, aliquot and store at -20°C.

Target Details for EGFR (Matuzumab Biosimilar)

Target: EGFR (Matuzumab Biosimilar)

Abstract: EGFR (Matuzumab Biosimilar) Products

Background: ErbB-1, ERBB1, HER1, EGF, Epidermal growth factor receptor, Proto-oncogene c-ErbB-1, Receptor tyrosine-protein kinase erbB-1, EMD72000, mAb425, 425, mAb 425

UniProt: P00533