Phone:
+1 877 302 8632
Fax:
+1 888 205 9894 (Toll-free)
E-Mail:
orders@antibodies-online.com

Recombinant CD40L (Ruplizumab Biosimilar) antibody

Reactivity: Human FACS, WB, BR Host: Rabbit Monoclonal hu5c8 unconjugated Recombinant Antibody
Catalog No. ABIN5668047
  • Target See all CD40L (Ruplizumab Biosimilar) products
    CD40L (Ruplizumab Biosimilar)
    Antibody Type
    Recombinant Antibody
    Reactivity
    • 3
    • 1
    Human
    Host
    • 2
    • 1
    Rabbit
    Clonality
    • 3
    Monoclonal
    Conjugate
    • 3
    This CD40L (Ruplizumab Biosimilar) antibody is un-conjugated
    Application
    • 3
    • 2
    • 1
    • 1
    • 1
    Flow Cytometry (FACS), Western Blotting (WB), Blocking Reagent (BR)
    Specificity
    The antibody binds to CD40L with an IC50 of 0.845 μg/mL.
    Characteristics

    OriginalSpeciesName: Human

    OriginalFormat: IgG1

    Purification
    Purified antibody.
    Purity
    > 98 % as determined by SDS-PAGE
    Endotoxin Level
    Endotoxin is < 1.0 EU/mg as determined by the LAL method
    Immunogen
    Human CD40L
    Clone
    Hu5c8
    Isotype
    IgG kappa
  • Application Notes
    The antibody binds specifically to CD40L, a surface receptor expressed on activated T cells which acts as a costimulatory molecule to trigger immune responses. The antibody neutralises CD40L function, as it blocks the interaction between CD40 and CD40L. When injected into cynomolgus monkeys, the original therapeutic antibody was found to have a T1/2 of 531? ±?155 hours.
    Comment

    NOT FOR THERAPEUTIC USE - This is a research-grade biosimilar. This chimeric rabbit antibody was made using the variable domain sequences of the original Human IgG1 format, for improved compatibility with existing reagents, assays and techniques.

    Restrictions
    For Research Use only
  • Buffer
    PBS with 0.02 % Proclin 300.
    Preservative
    ProClin
    Precaution of Use
    This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
    Storage
    4 °C,-20 °C
    Storage Comment
    Store at 4°C for up to 3 months. For longer storage, aliquot and store at -20°C.
  • Target
    CD40L (Ruplizumab Biosimilar)
    Abstract
    CD40L (Ruplizumab Biosimilar) Products
    Synonyms
    CD154 antibody, CD40L antibody, HIGM1 antibody, IGM antibody, IMD3 antibody, T-BAM antibody, TNFSF5 antibody, TRAP antibody, gp39 antibody, hCD40L antibody, CD40 ligand antibody, CD40LG antibody
    Target Type
    Biosimilar
    Background
    CD154, CD40 ligand, tumour necrosis factor ligand superfamily member 5, TNFSF5, tumour necrosis factor related activation protein, TRAP
    UniProt
    P29965
You are here:
Support