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ALKBH7 antibody (AA 1-221)

ALKBH7 Reactivity: Human WB Host: Rabbit Polyclonal unconjugated
Catalog No. ABIN5664063
  • Target See all ALKBH7 Antibodies
    ALKBH7 (AlkB, Alkylation Repair Homolog 7 (ALKBH7))
    Binding Specificity
    AA 1-221
    Reactivity
    • 9
    • 8
    • 1
    Human
    Host
    • 9
    Rabbit
    Clonality
    • 9
    Polyclonal
    Conjugate
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    This ALKBH7 antibody is un-conjugated
    Application
    • 2
    • 2
    • 1
    Western Blotting (WB)
    Sequence
    MAGTGLLALR TLPGPSWVRG SGPSVLSRLQ DAAVVRPGFL STAEEETLSR ELEPELRRRR YEYDHWDAAI HGFRETEKSR WSEASRAILQ RVQAAAFGPG QTLLSSVHVL DLEARGYIKP HVDSIKFCGA TIAGLSLLSP SVMRLVHTQE PGEWLELLLE PGSLYILRGS ARYDFSHEIL RDEESFFGER RIPRGRRISV ICRSLPEGMG PGESGQPPPA C
    Cross-Reactivity
    Human, Mouse, Rat
    Characteristics
    Polyclonal Antibodies
    Purification
    Affinity purification
    Immunogen
    Recombinant fusion protein containing a sequence corresponding to amino acids 1-221 of human ALKBH7 (NP_115682.1).
    Isotype
    IgG
  • Application Notes
    WB,1:200 - 1:2000
    Restrictions
    For Research Use only
  • Buffer
    PBS with 0.02 % sodium azide,50 % glycerol, pH 7.3.
    Preservative
    Sodium azide
    Precaution of Use
    This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
    Storage
    -20 °C
    Storage Comment
    Store at -20°C. Avoid freeze / thaw cycles.
  • Target
    ALKBH7 (AlkB, Alkylation Repair Homolog 7 (ALKBH7))
    Alternative Name
    ALKBH7 (ALKBH7 Products)
    Synonyms
    ABH7 antibody, SPATA11 antibody, UNQ6002 antibody, 2310045B01Rik antibody, 2510008E23Rik antibody, Abh7 antibody, Spata11 antibody, alkB homolog 7 antibody, Alkbh7 antibody, ALKBH7 antibody
    Background
    May function as protein hydroxylase, can catalyze auto-hydroxylation at Leu-110 (in vitro, but this activity may be due to the absence of the true substrate. Required to induce programmed necrosis in response to DNA damage caused by cytotoxic alkylating agents. Acts by triggering the collapse of mitochondrial membrane potential and loss of mitochondrial function that leads to energy depletion and cell death. ALKBH7-mediated necrosis is probably required to prevent the accumulation of cells with DNA damage. Does not display DNA demethylase activity. Involved in fatty acid metabolism (By similarity.,ALKBH7,ABH7,SPATA11,UNQ6002,Epigenetics & Nuclear Signaling,DNA Damage & Repair,ALKBH7
    Molecular Weight
    24 kDa
    Gene ID
    84266
    UniProt
    Q9BT30
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