RXFP1 antibody (AA 68-162)

Catalog No. ABIN566200

Product Details anti-RXFP1 Antibody

Target: RXFP1 (Relaxin/insulin-Like Family Peptide Receptor 1 (RXFP1))

Binding Specificity: AA 68-162

Reactivity: Human

Host: Mouse

Clonality: Monoclonal

Conjugate: This RXFP1 antibody is un-conjugated

Application: Western Blotting (WB), ELISA

Purpose: Mouse monoclonal antibody raised against a partial recombinant LGR7.

Sequence: WSMQFDKYFA SYYKMTSQYP FEAETPECLV GSVPVQCLCQ GLELDCDETN LRAVPSVSSN VTAMSLQWNL IRKLPPDCFK NYHDLQKLYL QNNKI

Cross-Reactivity: Human

Characteristics: Antibody Reactive Against Recombinant Protein.

Immunogen: LGR7 (NP_067647, 68 a.a. ~ 162 a.a) partial recombinant protein with GST tag. MW of the GST tag alone is 26 KDa.

Clone: 3E3

Isotype: IgG2a

Application Details

Application Notes: Optimal working dilution should be determined by the investigator.

Restrictions: For Research Use only

Handling

Buffer: In 1x PBS, pH 7.4

Handling Advice: Aliquot to avoid repeated freezing and thawing.

Storage: -20 °C

Storage Comment: Store at -20°C or lower. Aliquot to avoid repeated freezing and thawing.

References for anti-RXFP1 antibody (ABIN566200)

Jelinic, Leo, Post Uiterweer, Sandow, Gooi, Wlodek, Conrad, Parkington, Tare, Parry: "Localization of relaxin receptors in arteries and veins, and region-specific increases in compliance and bradykinin-mediated relaxation after in vivo serelaxin treatment." in: FASEB journal : official publication of the Federation of American Societies for Experimental Biology, Vol. 28, Issue 1, pp. 275-87, (2014) (PubMed).

Ferlin, Menegazzo, Gianesello, Selice, Foresta: "Effect of relaxin on human sperm functions." in: Journal of andrology, Vol. 33, Issue 3, pp. 474-82, (2012) (PubMed).

Soh, Tiwari, Mahendroo, Conrad, Parry: "Relaxin regulates hyaluronan synthesis and aquaporins in the cervix of late pregnant mice." in: Endocrinology, Vol. 153, Issue 12, pp. 6054-64, (2012) (PubMed).

Vandevoort, Mtango, Latham, Stewart: "Primate preimplantation embryo is a target for relaxin during early pregnancy." in: Fertility and sterility, Vol. 96, Issue 1, pp. 203-7, (2011) (PubMed).

Ferlin, Pepe, Facciolli, Gianesello, Foresta: "Relaxin stimulates osteoclast differentiation and activation." in: Bone, Vol. 46, Issue 2, pp. 504-13, (2010) (PubMed).

Vodstrcil, Shynlova, Verlander, Wlodek, Parry: "Decreased expression of the rat myometrial relaxin receptor (RXFP1) in late pregnancy is partially mediated by the presence of the conceptus." in: Biology of reproduction, Vol. 83, Issue 5, pp. 818-24, (2010) (PubMed).

Feng, Agoulnik, Truong, Li, Creighton, Kaftanovskaya, Pereira, Han, Lopez-Berestein, Klonisch, Ittmann, Sood, Agoulnik: "Suppression of relaxin receptor RXFP1 decreases prostate cancer growth and metastasis." in: Endocrine-related cancer, Vol. 17, Issue 4, pp. 1021-33, (2010) (PubMed).

Kern, Bryant-Greenwood: "Characterization of relaxin receptor (RXFP1) desensitization and internalization in primary human decidual cells and RXFP1-transfected HEK293 cells." in: Endocrinology, Vol. 150, Issue 5, pp. 2419-28, (2009) (PubMed).

Target Details for RXFP1

Target: RXFP1 (Relaxin/insulin-Like Family Peptide Receptor 1 (RXFP1))

Alternative Name: RXFP1 (RXFP1 Products)

Synonyms: LGR7 antibody, RXFPR1 antibody, Gm1018 antibody, Lgr7 antibody, RXFP2 antibody, relaxin/insulin like family peptide receptor 1 antibody, relaxin/insulin-like family peptide receptor 1 antibody, RXFP1 antibody, rxfp1 antibody, Rxfp1 antibody

Background: Full Gene Name: relaxin/insulin-like family peptide receptor 1
Synonyms: LGR7,LGR7.1,LGR7.10,LGR7.2,MGC138347,MGC142177,RXFPR1

Gene ID: 59350

NCBI Accession: NM_021634

Pathways: Myometrial Relaxation and Contraction