TARDBP antibody (AA 1-260)

Catalog No. ABIN565080

Product Details anti-TARDBP Antibody

Target: TARDBP (TAR DNA Binding Protein (TARDBP))

Binding Specificity: AA 1-260

Reactivity: Human

Host: Mouse

Clonality: Monoclonal

Conjugate: This TARDBP antibody is un-conjugated

Application: Western Blotting (WB), ELISA, Immunofluorescence (IF), Immunoprecipitation (IP), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), RNA Interference (RNAi)

Purpose: Mouse monoclonal antibody raised against a partial recombinant TARDBP.

Sequence: MSEYIRVTED ENDEPIEIPS EDDGTVLLST VTAQFPGACG LRYRNPVSQC MRGVRLVEGI LHAPDAGWGN LVYVVNYPKD NKRKMDETDA SSAVKVKRAV QKTSDLIVLG LPWKTTEQDL KEYFSTFGEV LMVQVKKDLK TGHSKGFGFV RFTEYETQVK VMSQRHMIDG RWCDCKLPNS KQSQDEPLRS RKVFVGRCTE DMTEDELREF FSQYGDVMDV FIPKPFRAFA FVTFADDQIA QSLCGEDLII KGISVHISNA

Cross-Reactivity: Human

Characteristics: Antibody Reactive Against Recombinant Protein.

Immunogen: TARDBP (NP_031401.1, 1 a.a. ~ 260 a.a) partial recombinant protein with GST tag. MW of the GST tag alone is 26 KDa.

Clone: 2E2-D3

Isotype: IgG1

Application Details

Application Notes: Optimal working dilution should be determined by the investigator.

Restrictions: For Research Use only

Handling

Buffer: In 1x PBS, pH 7.4

Handling Advice: Aliquot to avoid repeated freezing and thawing.

Storage: -20 °C

Storage Comment: Store at -20°C or lower. Aliquot to avoid repeated freezing and thawing.

References for anti-TARDBP antibody (ABIN565080)

Lynch, Jaunmuktane, Sheerin, Phadke, Brandner, Milonas, Dean, Bajaj, McNicholas, Costello, Cronin, McGuigan, Rossor, Fox, Murphy, Chataway, Houlden: "Hereditary leukoencephalopathy with axonal spheroids: a spectrum of phenotypes from CNS vasculitis to parkinsonism in an adult onset leukodystrophy series." in: Journal of neurology, neurosurgery, and psychiatry, Vol. 87, Issue 5, pp. 512-9, (2016) (PubMed).

De Marco, Lomartire, Calvo, Risso, De Luca, Mostert, Mandrioli, Caponnetto, Borghero, Manera, Canosa, Moglia, Restagno, Fini, Tarella, Giordana, Rinaudo, Chiò: "Monocytes of patients with amyotrophic lateral sclerosis linked to gene mutations display altered TDP-43 subcellular distribution." in: Neuropathology and applied neurobiology, Vol. 43, Issue 2, pp. 133-153, (2016) (PubMed).

Gelpi, Höftberger, Graus, Ling, Holton, Dawson, Popovic, Pretnar-Oblak, Högl, Schmutzhard, Poewe, Ricken, Santamaria, Dalmau, Budka, Revesz, Kovacs: "Neuropathological criteria of anti-IgLON5-related tauopathy." in: Acta neuropathologica, Vol. 132, Issue 4, pp. 531-43, (2016) (PubMed).

Rosenbohm, Buckert, Gerischer, Walcher, Kassubek, Rottbauer, Ludolph, Bernhardt: "Early diagnosis of cardiac involvement in idiopathic inflammatory myopathy by cardiac magnetic resonance tomography." in: Journal of neurology, Vol. 262, Issue 4, pp. 949-56, (2015) (PubMed).

Iovino, Pfisterer, Holton, Lashley, Swingler, Calo, Treacy, Revesz, Parmar, Goedert, Muqit, Spillantini: "The novel MAPT mutation K298E: mechanisms of mutant tau toxicity, brain pathology and tau expression in induced fibroblast-derived neurons." in: Acta neuropathologica, Vol. 127, Issue 2, pp. 283-95, (2014) (PubMed).

Hebron, Chen, Miessau, Lonskaya, Moussa: "Parkin reverses TDP-43-induced cell death and failure of amino acid homeostasis." in: Journal of neurochemistry, Vol. 129, Issue 2, pp. 350-61, (2014) (PubMed).

Suárez-Calvet, Dols-Icardo, Lladó, Sánchez-Valle, Hernández, Amer, Antón-Aguirre, Alcolea, Fortea, Ferrer, van der Zee, Dillen, Van Broeckhoven, Molinuevo, Blesa, Clarimón, Lleó: "Plasma phosphorylated TDP-43 levels are elevated in patients with frontotemporal dementia carrying a C9orf72 repeat expansion or a GRN mutation." in: Journal of neurology, neurosurgery, and psychiatry, Vol. 85, Issue 6, pp. 684-91, (2014) (PubMed).

Yan, Wang, Wei, Gaertig, Lai, Li, Li: "TDP-43 causes differential pathology in neuronal versus glial cells in the mouse brain." in: Human molecular genetics, Vol. 23, Issue 10, pp. 2678-93, (2014) (PubMed).

De Marco, Lomartire, Mandili, Lupino, Buccinnà, Ramondetti, Moglia, Novelli, Piccinini, Mostert, Rinaudo, Chiò, Calvo: "Reduced cellular Ca(2+) availability enhances TDP-43 cleavage by apoptotic caspases." in: Biochimica et biophysica acta, Vol. 1843, Issue 4, pp. 725-34, (2014) (PubMed).

Cortese, Plagnol, Brady, Simone, Lashley, Acevedo-Arozena, de Silva, Greensmith, Holton, Hanna, Fisher, Fratta: "Widespread RNA metabolism impairment in sporadic inclusion body myositis TDP43-proteinopathy." in: Neurobiology of aging, Vol. 35, Issue 6, pp. 1491-8, (2014) (PubMed).

Ohta, Tremblay, Schneider, Bennett, Calon, Julien: "Interaction of transactive response DNA binding protein 43 with nuclear factor ?B in mild cognitive impairment with episodic memory deficits." in: Acta neuropathologica communications, Vol. 2, Issue 1, pp. 37, (2014) (PubMed).

Gelpi, Navarro-Otano, Tolosa, Gaig, Compta, Rey, Martí, Hernández, Valldeoriola, Reñé, Ribalta: "Multiple organ involvement by alpha-synuclein pathology in Lewy body disorders." in: Movement disorders : official journal of the Movement Disorder Society, Vol. 29, Issue 8, pp. 1010-8, (2014) (PubMed).

Carlomagno, Zhang, Davis, Lin, Cook, Dunmore, Tay, Menkosky, Cao, Petrucelli, Deture: "Casein kinase II induced polymerization of soluble TDP-43 into filaments is inhibited by heat shock proteins." in: PLoS ONE, Vol. 9, Issue 3, pp. e90452, (2014) (PubMed).

Kara, Kiely, Proukakis, Giffin, Love, Hehir, Rantell, Pandraud, Hernandez, Nacheva, Pittman, Nalls, Singleton, Revesz, Bhatia, Quinn, Hardy, Holton, Houlden: "A 6.4 Mb duplication of the ?-synuclein locus causing frontotemporal dementia and Parkinsonism: phenotype-genotype correlations." in: JAMA neurology, Vol. 71, Issue 9, pp. 1162-71, (2014) (PubMed).

Balasa, Gelpi, Rey, Vila, Ramió-Torrentà, Quiles Granado, Molina Latorre, Lepidi, Raoult, Saiz: "Clinical and neuropathological variability in clinically isolated central nervous system Whipple's disease." in: Brain pathology (Zurich, Switzerland), Vol. 24, Issue 3, pp. 230-8, (2014) (PubMed).

Araki, Minegishi, Motoki, Kume, Hohjoh, Araki, Tamaoka: "Disease-associated mutations of TDP-43 promote turnover of the protein through the proteasomal pathway." in: Molecular neurobiology, Vol. 50, Issue 3, pp. 1049-58, (2014) (PubMed).

Hans, Fiesel, Strong, Jäckel, Rasse, Geisler, Springer, Schulz, Voigt, Kahle: "UBE2E ubiquitin-conjugating enzymes and ubiquitin isopeptidase Y regulate TDP-43 protein ubiquitination." in: The Journal of biological chemistry, Vol. 289, Issue 27, pp. 19164-79, (2014) (PubMed).

Robinson, Thompson, Weedon, Rollinson, Pickering-Brown, Snowden, Davidson, Mann: "No interaction between tau and TDP-43 pathologies in either frontotemporal lobar degeneration or motor neurone disease." in: Neuropathology and applied neurobiology, Vol. 40, Issue 7, pp. 844-54, (2014) (PubMed).

Alafuzoff, Pikkarainen, Neumann, Arzberger, Al-Sarraj, Bodi, Bogdanovic, Bugiani, Ferrer, Gelpi, Gentleman, Giaccone, Graeber, Hortobagyi, Ince, Ironside, Kavantzas, King, Korkolopoulou, Kovács et al.: "Neuropathological assessments of the pathology in frontotemporal lobar degeneration with TDP43-positive inclusions: an inter-laboratory study by the BrainNet Europe consortium. ..." in: Journal of neural transmission (Vienna, Austria : 1996), (2014) (PubMed).

Wenqiang, Lonskaya, Hebron, Ibrahim, Olszewski, Neale, Moussa: "Parkin-mediated reduction of nuclear and soluble TDP-43 reverses behavioral decline in symptomatic mice." in: Human molecular genetics, Vol. 23, Issue 18, pp. 4960-9, (2014) (PubMed).

Target Details for TARDBP

Target: TARDBP (TAR DNA Binding Protein (TARDBP))

Alternative Name: TARDBP (TARDBP Products)

Synonyms: TARDBP antibody, TDP43 antibody, DKFZp459I2127 antibody, tardbp antibody, ALS10 antibody, TDP-43 antibody, 1190002A23Rik antibody, C85084 antibody, Tdp43 antibody, wu:fb77f02 antibody, wu:fc52g10 antibody, TAR DNA binding protein antibody, Tardbp protein antibody, TAR DNA binding protein L homeolog antibody, TAR DNA-binding protein 43-like antibody, TARDBP antibody, tardbp antibody, tardbp.L antibody, Tardbp antibody, LOC100621383 antibody

Background: Full Gene Name: TAR DNA binding protein
Synonyms: ALS10,TDP-43

Gene ID: 23435

NCBI Accession: NM_007375

Pathways: Positive Regulation of Peptide Hormone Secretion