FGL2 antibody (AA 24-123)

Catalog No. ABIN564725

Product Details anti-FGL2 Antibody

Target: FGL2 (Fibrinogen-Like 2 (FGL2))

Binding Specificity: AA 24-123

Reactivity: Human

Host: Mouse

Clonality: Monoclonal

Conjugate: This FGL2 antibody is un-conjugated

Application: Western Blotting (WB), ELISA, Immunoprecipitation (IP), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))

Purpose: Mouse monoclonal antibody raised against a partial recombinant FGL2.

Sequence: NNETEEIKDE RAKDVCPVRL ESRGKCEEAG ECPYQVSLPP LTIQLPKQFS RIEEVFKEVQ NLKEIVNSLK KSCQDCKLQA DDNGDPGRNG LLLPSTGAPG

Cross-Reactivity: Human, Mouse, Rat

Characteristics: Antibody Reactive Against Recombinant Protein.

Immunogen: FGL2 (NP_006673, 24 a.a. ~ 123 a.a) partial recombinant protein with GST tag. MW of the GST tag alone is 26 KDa.

Clone: 6D9

Isotype: IgG2a

Application Details

Application Notes: Optimal working dilution should be determined by the investigator.

Restrictions: For Research Use only

Handling

Buffer: In 1x PBS, pH 7.4

Handling Advice: Aliquot to avoid repeated freezing and thawing.

Storage: -20 °C

Storage Comment: Store at -20°C or lower. Aliquot to avoid repeated freezing and thawing.

References for anti-FGL2 antibody (ABIN564725)

Long, You, Li, Jin, Huang, Li, Liu, Wang: "Sodium tanshinone IIA sulfonate ameliorates experimental coronary no-reflow phenomenon through down-regulation of FGL2." in: Life sciences, Vol. 142, pp. 8-18, (2015) (PubMed).

Dong, Ye, Chen, Chen, Xie, Li, Lin, Huang: "Intestinal and peripheral fibrinogen-like protein 2 expression in inflammatory bowel disease." in: Digestive diseases and sciences, Vol. 59, Issue 4, pp. 769-77, (2014) (PubMed).

Li, Wang, Long, Su, Bukhory, Dai, Jin, Huang, Jia, Li, Fan, Liu, Wang: "Novel antibody against a glutamic acid-rich human fibrinogen-like protein 2-derived peptide near Ser91 inhibits hfgl2 prothrombinase activity." in: PLoS ONE, Vol. 9, Issue 4, pp. e94551, (2014) (PubMed).

Sun, Xi, Ding, Wang, Zhou, Ning: "Soluble FGL2, a novel effector molecule of activated hepatic stellate cells, regulates T-cell function in cirrhotic patients with hepatocellular carcinoma." in: Hepatology international, Vol. 8, Issue 4, pp. 567-575, (2014) (PubMed).

Xu, Chen, Yang, Li, Zheng, Wu: "C5a/C5aR pathway is essential for the pathogenesis of murine viral fulminant hepatitis by way of potentiating Fgl2/fibroleukin expression." in: Hepatology (Baltimore, Md.), Vol. 60, Issue 1, pp. 114-24, (2014) (PubMed).

Xi, Wang, Ye, Luo, Ning: "Combined adenovirus-mediated artificial microRNAs targeting mfgl2, mFas, and mTNFR1 protect against fulminant hepatic failure in mice." in: PLoS ONE, Vol. 8, Issue 11, pp. e82330, (2013) (PubMed).

Ye, Huai, Chen, Ding, Chen, Cai: "Correlation of fibrinogen-like protein 2 with disease progression in patients with severe acute pancreatitis." in: Experimental and therapeutic medicine, Vol. 7, Issue 1, pp. 85-89, (2013) (PubMed).

Selzner, Liu, Boehnert, Adeyi, Shalev, Bartczak, Xue-Zhong, Manuel, Rotstein, McGilvray, Grant, Phillips, Levy, Selzner: "FGL2/fibroleukin mediates hepatic reperfusion injury by induction of sinusoidal endothelial cell and hepatocyte apoptosis in mice." in: Journal of hepatology, Vol. 56, Issue 1, pp. 153-9, (2011) (PubMed).

Liu, Xu, Xiao, Xiong, Wang, Gao, Yan, Ning: "The FGL2/fibroleukin prothrombinase is involved in alveolar macrophage activation in COPD through the MAPK pathway." in: Biochemical and biophysical research communications, Vol. 396, Issue 2, pp. 555-61, (2010) (PubMed).

OBrien, Morrison, Smith: "Expression of prothrombin and protease activated receptors in human myometrium during pregnancy and labor." in: Biology of reproduction, Vol. 78, Issue 1, pp. 20-6, (2007) (PubMed).

Shalev, Liu, Koscik, Bartczak, Javadi, Wong, Maknojia, He, Liu, Diao, Winter, Manuel, McCarthy, Cattral, Gommerman, Clark, Phillips, Gorczynski, Zhang, Downey, Grant, Cybulsky, Levy: "Targeted deletion of fgl2 leads to impaired regulatory T cell activity and development of autoimmune glomerulonephritis." in: Journal of immunology (Baltimore, Md. : 1950), Vol. 180, Issue 1, pp. 249-60, (2007) (PubMed).

Target Details for FGL2

Target: FGL2 (Fibrinogen-Like 2 (FGL2))

Alternative Name: FGL2 (FGL2 Products)

Synonyms: FGL2 antibody, wu:fj83c10 antibody, zgc:136619 antibody, si:ch211-276e22.3 antibody, fibroleukin antibody, T49 antibody, pT49 antibody, AI385601 antibody, musfiblp antibody, fibrinogen like 2 antibody, fibrinogen like 2 L homeolog antibody, fibrinogen-like 2a antibody, fibrinogen-like 2 antibody, fibrinogen-like protein 2 antibody, FGL2 antibody, fgl2.L antibody, fgl2a antibody, Fgl2 antibody

Background: Full Gene Name: fibrinogen-like 2
Synonyms: T49,pT49

Gene ID: 10875

NCBI Accession: NM_006682