LASS1 antibody (AA 301-350)

Catalog No. ABIN564667

Product Details anti-LASS1 Antibody

Target: LASS1 (CERS1) (Ceramide Synthase 1 (CERS1))

Binding Specificity: AA 301-350

Reactivity: Human

Host: Mouse

Clonality: Polyclonal

Conjugate: This LASS1 antibody is un-conjugated

Application: Western Blotting (WB), ELISA

Purpose: Mouse polyclonal antibody raised against a partial recombinant LASS1.

Sequence: YIVAFAAKVL TGQVHELKDL REYDTAEAQS LKPSKAEKPL RNGLVKDKRF

Cross-Reactivity: Human

Characteristics: Antibody Reactive Against Recombinant Protein.

Immunogen: LASS1 (NP_067090, 301 a.a. ~ 350 a.a) partial recombinant protein with GST tag.

Application Details

Application Notes: Optimal working dilution should be determined by the investigator.

Restrictions: For Research Use only

Handling

Format: Liquid

Buffer: 50 % glycerol

Handling Advice: Aliquot to avoid repeated freezing and thawing.

Storage: -20 °C

Storage Comment: Store at -20°C or lower. Aliquot to avoid repeated freezing and thawing.

References for anti-LASS1 antibody (ABIN564667)

Separovic, Breen, Joseph, Bielawski, Pierce, VAN Buren, Gudz: "Ceramide synthase 6 knockdown suppresses apoptosis after photodynamic therapy in human head and neck squamous carcinoma cells." in: Anticancer research, Vol. 32, Issue 3, pp. 753-60, (2012) (PubMed).

Separovic, Breen, Joseph, Bielawski, Pierce, VAN Buren, Gudz: "siRNA-mediated down-regulation of ceramide synthase 1 leads to apoptotic resistance in human head and neck squamous carcinoma cells after photodynamic therapy." in: Anticancer research, Vol. 32, Issue 7, pp. 2479-85, (2012) (PubMed).

Haddad, Khoury, Daoud, Kantar, Harati, Mousallem, Alzate, Meyer, Boustany: "CLN5 and CLN8 protein association with ceramide synthase: biochemical and proteomic approaches." in: Electrophoresis, Vol. 33, Issue 24, pp. 3798-809, (2012) (PubMed).

Senkal, Ponnusamy, Bielawski, Hannun, Ogretmen: "Antiapoptotic roles of ceramide-synthase-6-generated C16-ceramide via selective regulation of the ATF6/CHOP arm of ER-stress-response pathways." in: FASEB journal : official publication of the Federation of American Societies for Experimental Biology, Vol. 24, Issue 1, pp. 296-308, (2010) (PubMed).

Senkal, Ponnusamy, Rossi, Bialewski, Sinha, Jiang, Jazwinski, Hannun, Ogretmen: "Role of human longevity assurance gene 1 and C18-ceramide in chemotherapy-induced cell death in human head and neck squamous cell carcinomas." in: Molecular cancer therapeutics, Vol. 6, Issue 2, pp. 712-22, (2007) (PubMed).

Target Details for LASS1

Target: LASS1 (CERS1) (Ceramide Synthase 1 (CERS1))

Alternative Name: LASS1 (CERS1 Products)

Synonyms: LAG1 antibody, LASS1 antibody, UOG1 antibody, Lass1 antibody, Uog-1 antibody, to antibody, LAG1 HOMOLOG 1 antibody, LONGEVITY ASSURANCE GENE 1 antibody, ceramide synthase 1 antibody, TRAM, LAG1 and CLN8 (TLC) lipid-sensing domain containing protein antibody, CERS1 antibody, Cers1 antibody, LAG1 antibody

Background: Full Gene Name: LAG1 homolog, ceramide synthase 1
Synonyms: CerS1,LAG1,MGC90349,UOG1

Gene ID: 10715

NCBI Accession: NM_021267