Claudin 1 antibody (AA 1-211)

Catalog No. ABIN563931

Product Details anti-Claudin 1 Antibody

Target: Claudin 1 (CLDN1)

Binding Specificity: AA 1-211

Reactivity: Human

Host: Mouse

Clonality: Monoclonal

Conjugate: This Claudin 1 antibody is un-conjugated

Application: Western Blotting (WB), ELISA, Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Immunoprecipitation (IP)

Purpose: Mouse monoclonal antibody raised against a full length recombinant CLDN1.

Sequence: MANAGLQLLG FILAFLGWIG AIVSTALPQW RIYSYAGDNI VTAQAMYEGL WMSCVSQSTG QIQCKVFDSL LNLSSTLQAT RALMVVGILL GVIAIFVATV GMKCMKCLED DEVQKMRMAV IGGAIFLLAG LAILVATAWY GNRIVQEFYD PMTPVNARYE FGQALFTGWA AASLCLLGGA LLCCSCPRKT TSYPTPRPYP KPAPSSGKDY V

Cross-Reactivity: Human

Characteristics: Antibody Reactive Against Recombinant Protein.

Immunogen: CLDN1 (AAH12471.1, 1 a.a. ~ 211 a.a) full-length recombinant protein with GST tag. MW of the GST tag alone is 26 KDa.

Clone: 1C5-D9

Isotype: IgG2a

Application Details

Application Notes: Optimal working dilution should be determined by the investigator.

Restrictions: For Research Use only

Handling

Buffer: In 1x PBS, pH 7.4

Handling Advice: Aliquot to avoid repeated freezing and thawing.

Storage: -20 °C

Storage Comment: Store at -20°C or lower. Aliquot to avoid repeated freezing and thawing.

References for anti-Claudin 1 antibody (ABIN563931)

Giugliano, Petroff, Warren, Jasti, Linscheid, Ward, Kramer, Dobrinskikh, Sheiko, Gale, Golden-Mason, Winn, Rosen: "Hepatitis C Virus Sensing by Human Trophoblasts Induces Innate Immune Responses and Recruitment of Maternal NK Cells: Potential Implications for Limiting Vertical Transmission." in: Journal of immunology (Baltimore, Md. : 1950), Vol. 195, Issue 8, pp. 3737-47, (2015) (PubMed).

Miki, Hamada, Yoshino, Miyatani, Takahashi: "Type AB thymoma is not a mixed tumor of type A and type B thymomas, but a distinct type of thymoma." in: Virchows Archiv : an international journal of pathology, Vol. 464, Issue 6, pp. 725-34, (2014) (PubMed).

Kitazawa, Kawasaki, Shinomiya, Aoi, Matsuda, Funaki, Yamasaki, Nakatsukasa, Ebihara, Murakami, Hamuro, Kinoshita: "Establishment of a human corneal epithelial cell line lacking the functional TACSTD2 gene as an in vitro model for gelatinous drop-like dystrophy." in: Investigative ophthalmology & visual science, Vol. 54, Issue 8, pp. 5701-11, (2013) (PubMed).

Ratovitski: "Phospho-?Np63? regulates AQP3, ALOX12B, CASP14 and CLDN1 expression through transcription and microRNA modulation." in: FEBS letters, Vol. 587, Issue 21, pp. 3581-6, (2013) (PubMed).

Fletcher, Wilson, Murray, Hu, Lewis, Reynolds, Stamataki, Meredith, Rowe, Luo, Lopez-Ramirez, Baumert, Weksler, Couraud, Kim, Romero, Jopling, Morgello, Balfe, McKeating: "Hepatitis C virus infects the endothelial cells of the blood-brain barrier." in: Gastroenterology, Vol. 142, Issue 3, pp. 634-643.e6, (2012) (PubMed).

Sainz, Barretto, Yu, Corcoran, Uprichard: "Permissiveness of human hepatoma cell lines for HCV infection." in: Virology journal, Vol. 9, pp. 30, (2012) (PubMed).

Florentin, Aouar, Dental, Thumann, Firaguay, Gondois-Rey, Soumelis, Baumert, Nunès, Olive, Hirsch, Stranska: "HCV glycoprotein E2 is a novel BDCA-2 ligand and acts as an inhibitor of IFN production by plasmacytoid dendritic cells." in: Blood, Vol. 120, Issue 23, pp. 4544-51, (2012) (PubMed).

Shaykhiev, Otaki, Bonsu, Dang, Teater, Strulovici-Barel, Salit, Harvey, Crystal: "Cigarette smoking reprograms apical junctional complex molecular architecture in the human airway epithelium in vivo." in: Cellular and molecular life sciences : CMLS, Vol. 68, Issue 5, pp. 877-92, (2011) (PubMed).

Kanki, Kohro, Jiang, Tsutsumi, Mimura, Suehiro, Wada, Ohta, Ihara, Iwanari, Naito, Hamakubo, Aburatani, Kodama, Minami: "Epigenetically coordinated GATA2 binding is necessary for endothelium-specific endomucin expression." in: The EMBO journal, Vol. 30, Issue 13, pp. 2582-95, (2011) (PubMed).

Nakatsukasa, Kawasaki, Yamasaki, Fukuoka, Matsuda, Tsujikawa, Tanioka, Nagata-Takaoka, Hamuro, Kinoshita: "Tumor-associated calcium signal transducer 2 is required for the proper subcellular localization of claudin 1 and 7: implications in the pathogenesis of gelatinous drop-like corneal dystrophy." in: The American journal of pathology, Vol. 177, Issue 3, pp. 1344-55, (2010) (PubMed).

Stamataki, Shannon-Lowe, Shaw, Mutimer, Rickinson, Gordon, Adams, Balfe, McKeating: "Hepatitis C virus association with peripheral blood B lymphocytes potentiates viral infection of liver-derived hepatoma cells." in: Blood, Vol. 113, Issue 3, pp. 585-93, (2009) (PubMed).

Sainz, TenCate, Uprichard: "Three-dimensional Huh7 cell culture system for the study of Hepatitis C virus infection." in: Virology journal, Vol. 6, pp. 103, (2009) (PubMed).

Guévin, Lamarre, Labonté: "Novel HCV replication mouse model using human hepatocellular carcinoma xenografts." in: Antiviral research, Vol. 84, Issue 1, pp. 14-22, (2009) (PubMed).

Harris, Farquhar, Mee, Davis, Reynolds, Jennings, Hu, Yuan, Deng, Hubscher, Han, Balfe, McKeating: "CD81 and claudin 1 coreceptor association: role in hepatitis C virus entry." in: Journal of virology, Vol. 82, Issue 10, pp. 5007-20, (2008) (PubMed).

Farquhar, Harris, Diskar, Jones, Mee, Nielsen, Brimacombe, Molina, Toms, Maurel, Howl, Herberg, van Ijzendoorn, Balfe, McKeating: "Protein kinase A-dependent step(s) in hepatitis C virus entry and infectivity." in: Journal of virology, Vol. 82, Issue 17, pp. 8797-811, (2008) (PubMed).

Mee, Grove, Harris, Hu, Balfe, McKeating: "Effect of cell polarization on hepatitis C virus entry." in: Journal of virology, Vol. 82, Issue 1, pp. 461-70, (2007) (PubMed).

Target Details for Claudin 1

Target: Claudin 1 (CLDN1)

Alternative Name: CLDN1 (CLDN1 Products)

Synonyms: CLD1 antibody, ILVASC antibody, SEMP1 antibody, AI596271 antibody, cldn19 antibody, claudin-1 antibody, cld1 antibody, ilvasc antibody, semp1 antibody, CLDN1 antibody, claudin 1 antibody, claudin 1 S homeolog antibody, CLDN1 antibody, Cldn1 antibody, cldn1 antibody, cldn1.S antibody

Background: Full Gene Name: claudin 1
Synonyms: CLD1,ILVASC,SEMP1

Gene ID: 9076

Pathways: Cell-Cell Junction Organization, Hepatitis C