YARS antibody (AA 1-528)

Catalog No. ABIN563694

Product Details anti-YARS Antibody

Target: YARS (Yars) (Tyrosyl-tRNA Synthetase (Yars))

Binding Specificity: AA 1-528

Reactivity: Human

Host: Mouse

Clonality: Monoclonal

Conjugate: This YARS antibody is un-conjugated

Application: Western Blotting (WB), ELISA

Purpose: Mouse monoclonal antibody raised against a full length recombinant YARS.

Sequence: MGDAPSPEEK LHLITRNLQE VLGEEKLKEI LKERELKIYW GTATTGKPHV AYFVPMSKIA DFLKAGCEVT ILFADLHAYL DNMKAPWELL ELRVSYYENV IKAMLESIGV PLEKLKFIKG TDYQLSKEYT LDVYRLSSVV TQHDSKKAGA EVVKQVEHPL LSGLLYPGLQ ALDEEYLKVD AQFGGIDQRK IFTFAEKYLP ALGYSKRVHL MNPMVPGLTG SKMSSSEEES KIDLLDRKED VKKKLKKAFC EPGNVENNGV LSFIKHVLFP LKSEFVILRD EKWGGNKTYT AYVDLEKDFA AEVVHPGDLK NSVEVALNKL LDPIREKFNT PALKKLASAA YPDPSKQKPM AKGPAKNSEP EEVIPSRLDI RVGKIITVEK HPDADSLYVE KIDVGEAEPR TVVSGLVQFV PKEELQDRLV VVLCNLKPQK MRGVESQGML LCASIEGINR QVEPLDPPAG SAPGEHVFVK GYEKGQPDEE LKPKKKVFEK LQADFKISEE CIAQWKQTNF MTKLGSISCK SLKGGNIS

Cross-Reactivity: Human, Mouse

Characteristics: Antibody Reactive Against Recombinant Protein.

Immunogen: YARS (AAH01933, 1 a.a. ~ 528 a.a) full-length recombinant protein with GST tag. MW of the GST tag alone is 26 KDa.

Clone: 2F3

Isotype: IgG1

Application Details

Application Notes: Optimal working dilution should be determined by the investigator.

Restrictions: For Research Use only

Handling

Buffer: In 1x PBS, pH 7.4

Handling Advice: Aliquot to avoid repeated freezing and thawing.

Storage: -20 °C

Storage Comment: Store at -20°C or lower. Aliquot to avoid repeated freezing and thawing.

References for anti-YARS antibody (ABIN563694)

Niehues, Bussmann, Steffes, Erdmann, Köhrer, Sun, Wagner, Schäfer, Wang, Koerdt, Stum, RajBhandary, Thomas, Aberle, Burgess, Yang, Dieterich, Storkebaum: "Impaired protein translation in Drosophila models for Charcot-Marie-Tooth neuropathy caused by mutant tRNA synthetases." in: Nature communications, Vol. 6, pp. 7520, (2015) (PubMed).

Storkebaum, Leitão-Gonçalves, Godenschwege, Nangle, Mejia, Bosmans, Ooms, Jacobs, Van Dijck, Yang, Schimmel, Norga, Timmerman, Callaerts, Jordanova: "Dominant mutations in the tyrosyl-tRNA synthetase gene recapitulate in Drosophila features of human Charcot-Marie-Tooth neuropathy." in: Proceedings of the National Academy of Sciences of the United States of America, Vol. 106, Issue 28, pp. 11782-7, (2009) (PubMed).

Target Details for YARS

Target: YARS (Yars) (Tyrosyl-tRNA Synthetase (Yars))

Alternative Name: YARS (Yars Products)

Synonyms: CMTDIC antibody, TYRRS antibody, YRS antibody, YTS antibody, AL024047 antibody, AU018965 antibody, cb204 antibody, wu:fk52b08 antibody, YARS antibody, cmtdic antibody, tyrrs antibody, yrs antibody, yts antibody, CG4561 antibody, Dmel\\CG4561 antibody, TyrRS antibody, anon-EST:Posey261 antibody, dYARS antibody, GB10789 antibody, tyrosyl-tRNA synthetase antibody, tyrosyl-tRNA synthetase L homeolog antibody, tyrosyl-tRNA synthetase, putative antibody, tyrosine--tRNA ligase antibody, Tyrosyl-tRNA synthetase antibody, tyrosine--tRNA ligase, cytoplasmic antibody, YARS antibody, Yars antibody, yars antibody, yars.L antibody, MAL8P1.125 antibody, MEFER_RS04475 antibody, TyrRS antibody, LOC413909 antibody, LOC100163888 antibody, LOC100282315 antibody

Background: Full Gene Name: tyrosyl-tRNA synthetase
Synonyms: CMTDIC,TYRRS,YRS,YTS

Gene ID: 8565