RRAS2 antibody (PE)

Catalog No. ABIN5633276

Product Details anti-RRAS2 Antibody (PE)

Target: RRAS2 (Related RAS Viral (R-Ras) Oncogene Homolog 2 (RRAS2))

Reactivity: Human

Host: Mouse

Clonality: Monoclonal

Conjugate: This RRAS2 antibody is conjugated to PE

Application: Flow Cytometry (FACS)

Specificity: The mouse monoclonal antibody EM-50 recognizes R-Ras2 / TC21 protein (intracellular antigen) and does not react with R-Ras1, H-Ras, K-Ras, and N-Ras.

Cross-Reactivity (Details): Human

Purification: Purified antibody is conjugated with R-phycoerythrin (PE) under optimum conditions. Unconjugated antibody and free fluorochrome are removed by size-exclusion chromatography.

Immunogen: Human TC21

Clone: EM-50

Isotype: IgG1 kappa

Application Details

Application Notes: Flow cytometry: Recommended dilution: 1-4 μg/mL. Intracellular staining.

Comment:

The purified antibody is conjugated with R-Phycoerythrin (PE) under optimum conditions. The conjugate is purified by size-exclusion chromatography.

Restrictions: For Research Use only

Handling

Concentration: 0.1 mg/mL

Buffer: Stabilizing phosphate buffered saline (PBS), pH 7.4, 15 mM sodium azide

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: 4 °C

Storage Comment: Store at 2-8°C. Protect from prolonged exposure to light. Do not freeze.

Target Details for RRAS2

Target: RRAS2 (Related RAS Viral (R-Ras) Oncogene Homolog 2 (RRAS2))

Alternative Name: R-Ras2 / TC21 (RRAS2 Products)

Synonyms: TC21 antibody, 2610016H24Rik antibody, C86394 antibody, Ras-related protein R-Ras2 antibody, RAS related 2 antibody, related RAS viral (r-ras) oncogene 2 antibody, related RAS viral (r-ras) oncogene homolog 2 antibody, TVAG_453070 antibody, Bm1_46660 antibody, RRAS2 antibody, Rras2 antibody

Background: RAS related 2,R-Ras2 / TC21 is the only member of R-Ras family of small GTPases that shows transforming activities similar to H-Ras, N-Ras, and K-Ras, and it is also structurally similar to them. R-Ras2 seems to play an important role in activating signal transduction pathways that control cell proliferation. Its mutations are associated with the growth of certain tumors, but also overexpression of the wild type form of R-Ras2 has been frequently detected in various carcinomas. Pseudogenes of R-Ras2 gene are found on chromosomes 1 and 2. Alternate splicing results in multiple transcript variants.,TC21, RRAS2

Gene ID: 22800

UniProt: P62070