CD57 antibody (FITC)

Catalog No. ABIN5633274

Product Details anti-CD57 Antibody (FITC)

Target: CD57 (B3GAT1) (beta-1,3-Glucuronyltransferase 1 (Glucuronosyltransferase P) (B3GAT1))

Reactivity: Human

Host: Mouse

Clonality: Monoclonal

Conjugate: This CD57 antibody is conjugated to FITC

Application: Flow Cytometry (FACS)

Specificity: The mouse monoclonal antibody TB01 recognizes CD57, a carbohydrate extracellular antigen present mainly on NK cells, NK T cells, and in neural tissue.

Cross-Reactivity (Details): Human

Purification: Purified antibody is conjugated with fluorescein isothiocyanate (FITC) under optimum conditions and unconjugated antibody and free fluorochrome are removed by size-exclusion chromatography.

Immunogen: A pool of neuroblastoma cell lines

Clone: TB01

Isotype: IgM

Application Details

Application Notes: Flow cytometry: The reagent is designed for analysis of human blood cells using 4 μL reagent / 100 μL of whole blood or 10⁶ cells in a suspension. The content of a vial (0.4 ml) is sufficient for 100 tests.

Comment:

The purified antibody is conjugated with Fluorescein isothiocyanate (FITC) under optimum conditions. The reagent is free of unconjugated FITC and adjusted for direct use. No reconstitution is necessary.

Restrictions: For Research Use only

Handling

Buffer: Stabilizing Tris buffered saline (TBS), pH 8.0, 15 mM sodium azide

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: 4 °C

Storage Comment: Store at 2-8°C. Protect from prolonged exposure to light. Do not freeze.

Target Details for CD57

Target: CD57 (B3GAT1) (beta-1,3-Glucuronyltransferase 1 (Glucuronosyltransferase P) (B3GAT1))

Alternative Name: CD57 (B3GAT1 Products)

Synonyms: CD57 antibody, GLCATP antibody, GLCUATP antibody, HNK1 antibody, LEU7 antibody, NK-1 antibody, NK1 antibody, 0710007K08Rik antibody, AI846286 antibody, GlcAT-P antibody, Glcatp antibody, Hnk1 antibody, Hnk-1 antibody, b3gat1 antibody, si:dkey-22o20.1 antibody, cd57 antibody, glcatp antibody, glcuatp antibody, hnk-1 antibody, hnk1 antibody, leu7 antibody, nk-1 antibody, nk1 antibody, beta-1,3-glucuronyltransferase 1 antibody, beta-1,3-glucuronyltransferase 1 (glucuronosyltransferase P) antibody, beta-1,3-glucuronyltransferase 1 (glucuronosyltransferase P) a antibody, beta-1,3-glucuronyltransferase 1 L homeolog antibody, B3GAT1 antibody, B3gat1 antibody, b3gat1a antibody, b3gat1.L antibody

Background: Beta-1,3-glucuronyltransferase 1,CD57, also known as HNK1 or Leu7, is a sulphated trisaccharide (3-O-sulfoglucuronic acid beta1-3 Gal beta1-4 GlcNAc) attached to several glycoproteins, including CD56, myelin glycoprotein PO, and neural cell adhesion molecule L1, as well as on glycolipids and chondroitin sulphate proteoglycans in the nervous system. It serves as a NK cell marker and it is expressed on well differentiated prostate cancers and uveal and cutaneous melanoma. CD57+ T cells are implicated as suppressors of T-cell responses.,HNK1, LEU7, 3-O-sulfoglucuronic acid beta1-3 Gal beta1-4 GlcNAc

Gene ID: 27087

UniProt: Q9P2W7

Pathways: Glycosaminoglycan Metabolic Process