CD41, CD61 antibody
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- Target See all CD41, CD61 Antibodies
- CD41, CD61 (CD41,CD61)
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Reactivity
- Human
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Host
- Mouse
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Clonality
- Monoclonal
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Conjugate
- This CD41, CD61 antibody is un-conjugated
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Application
- Flow Cytometry (FACS), Immunoprecipitation (IP), Immunocytochemistry (ICC)
- Specificity
- The mouse monoclonal antibody PAC-1 recognizes an extracellular activation-induced conformational epitope PAC-1 on CD41/CD61 complex (gpIIb/IIIa), also known as integrin alpha IIb beta 3, a receptor which mediates platelet aggregation.
- Cross-Reactivity (Details)
- Human
- Purification
- Purified by sequential steps of physicochemical fractionation (differential precipitation and solid-phase chromatography methods).
- Purity
- > 95 % (by SDS-PAGE)
- Immunogen
- Human platelets
- Clone
- PAC-1
- Isotype
- IgM kappa
- Top Product
- Discover our top product CD41, CD61 Primary Antibody
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anti-CD41,CD61 antibody
Reactivity: Human, Cow FACS, IP, ELISA, ICC Host: Mouse Monoclonal IVA30 unconjugated
anti-CD41,CD61 antibody (PE)Reactivity: Human FACS Host: Mouse Monoclonal PAC-1 PE
anti-CD41,CD61 antibody (PerCP)Reactivity: Human FACS Host: Mouse Monoclonal PAC-1 PerCP
anti-CD41,CD61 antibody (FITC)Reactivity: Human FACS Host: Mouse Monoclonal PAC-1 FITC
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- Application Notes
- Flow cytometry: Recommended dilution: 2-4 μg/mL.
- Restrictions
- For Research Use only
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- Concentration
- 1 mg/mL
- Buffer
- Tris buffered saline (TBS), pH 8.0, 15 mM sodium azide
- Preservative
- Sodium azide
- Precaution of Use
- This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
- Storage
- 4 °C
- Storage Comment
- Store at 2-8°C. Do not freeze.
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- Target
- CD41, CD61 (CD41,CD61)
- Alternative Name
- CD41/CD61 (CD41, CD61 Products)
- Background
- CD41 (platelet glycoprotein IIb, integrin alpha IIb) is composed of two subunits (120 kDa transmembrane alpha chain and 23 kDa extracellular beta chain) and interacts with CD61 (platelet glycoprotein IIIa, integrin beta 3) in the presence of calcium to form a functional adhesive protein receptor. CD41/CD61 complex is one of the earliest markers of the megakaryocytic lineage. Upon blood vessel damage, this receptor binds to a variety of proteins including von Willebrand factor, fibrinogen, fibronectin and vitronectin, and it is involved in platelet aggregation.,platelet GPIIb, Integrin alpha-Iib, GPalpha IIb, GPIIb, GT, GP3A, platelet GPIIIa
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