TPMT antibody (AA 1-245)

Catalog No. ABIN563239

Product Details anti-TPMT Antibody

Target: TPMT (Thiopurine S-Methyltransferase (TPMT))

Binding Specificity: AA 1-245

Reactivity: Human

Host: Mouse

Clonality: Monoclonal

Conjugate: This TPMT antibody is un-conjugated

Application: Western Blotting (WB), ELISA, Immunofluorescence (IF), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))

Purpose: Mouse monoclonal antibody raised against a full length recombinant TPMT.

Sequence: MDGTRTSLDI EEYSDTEVQK NQVLTLEEWQ DKWVNGKTAF HQEQGHQLLK KHLDTFLKGK SGLRVFFPLC GKAVEMKWFA DRGHSVVGVE ISELGIQEFF TEQNLSYSEE PITEIPGTKV FKSSSGNISL YCCSIFDLPR TNIGKFDMIW DRGALVAINP GDRKCYADTM FSLLGKKFQY LLCVLSYDPT KHPGPPFYVP HAEIERLFGK ICNIRRLEKV DAFEERHKSW GIDCLFEKLY LLTEK

Cross-Reactivity: Human

Characteristics: Antibody Reactive Against Recombinant Protein.

Immunogen: TPMT (AAH05339, 1 a.a. ~ 245 a.a) full-length recombinant protein with GST tag. MW of the GST tag alone is 26 KDa.

Clone: 1B5

Isotype: IgG1

Application Details

Application Notes: Optimal working dilution should be determined by the investigator.

Restrictions: For Research Use only

Handling

Buffer: In 1x PBS, pH 7.4

Handling Advice: Aliquot to avoid repeated freezing and thawing.

Storage: -20 °C

Storage Comment: Store at -20°C or lower. Aliquot to avoid repeated freezing and thawing.

References for anti-TPMT antibody (ABIN563239)

Milek, Karas Kuzelicki, Smid, Mlinaric-Rascan: "S-adenosylmethionine regulates thiopurine methyltransferase activity and decreases 6-mercaptopurine cytotoxicity in MOLT lymphoblasts." in: Biochemical pharmacology, Vol. 77, Issue 12, pp. 1845-53, (2009) (PubMed).

Egle, Milek, Mlinaric-Rascan, Fahr, Kristl: "A novel gene delivery system for stable transfection of thiopurine-S-methyltransferase gene in versatile cell types." in: European journal of pharmaceutics and biopharmaceutics : official journal of Arbeitsgemeinschaft für Pharmazeutische Verfahrenstechnik e.V, Vol. 69, Issue 1, pp. 23-30, (2008) (PubMed).

Target Details for TPMT

Target: TPMT (Thiopurine S-Methyltransferase (TPMT))

Alternative Name: TPMT (TPMT Products)

Background: Full Gene Name: thiopurine S-methyltransferase
Synonyms:

Gene ID: 7172