PPOX antibody (AA 378-477)

Catalog No. ABIN562343

Product Details anti-PPOX Antibody

Target: PPOX (Protoporphyrinogen Oxidase (PPOX))

Binding Specificity: AA 378-477

Reactivity: Human

Host: Mouse

Clonality: Monoclonal

Conjugate: This PPOX antibody is un-conjugated

Application: Western Blotting (WB), ELISA, Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), RNA Interference (RNAi)

Purpose: Mouse monoclonal antibody raised against a partial recombinant PPOX.

Sequence: EASGCVLSQE LFQQRAQEAA ATQLGLKEMP SHCLVHLHKN CIPQYTLGHW QKLESARQFL TAHRLPLTLA GASYEGVAVN DCIESGRQAA VSVLGTEPNS

Cross-Reactivity: Human

Characteristics: Antibody Reactive Against Recombinant Protein.

Immunogen: PPOX (AAH02357, 378 a.a. ~ 477 a.a) partial recombinant protein with GST tag. MW of the GST tag alone is 26 KDa.

Clone: 2F10

Isotype: IgG1

Application Details

Application Notes: Optimal working dilution should be determined by the investigator.

Restrictions: For Research Use only

Handling

Buffer: In 1x PBS, pH 7.4

Handling Advice: Aliquot to avoid repeated freezing and thawing.

Storage: -20 °C

Storage Comment: Store at -20°C or lower. Aliquot to avoid repeated freezing and thawing.

References for anti-PPOX antibody (ABIN562343)

Yang, Chen, Chiang, Huang, Lee, Liu, Chang, Hsu: "Improve efficacy of topical ALA-PDT by calcipotriol through up-regulation of coproporphyrinogen oxidase." in: Photodiagnosis and photodynamic therapy, Vol. 11, Issue 3, pp. 331-41, (2014) (PubMed).

Yang, Lee, Chen, Huang, Hsu: "Methotrexate enhances 5-aminolevulinic acid-mediated photodynamic therapy-induced killing of human SCC4 cells by upregulation of coproporphyrinogen oxidase." in: Journal of the Formosan Medical Association = Taiwan yi zhi, Vol. 113, Issue 2, pp. 88-93, (2014) (PubMed).

Crooks, Ghosh, Haller, Tong, Rouault: "Posttranslational stability of the heme biosynthetic enzyme ferrochelatase is dependent on iron availability and intact iron-sulfur cluster assembly machinery." in: Blood, Vol. 115, Issue 4, pp. 860-9, (2010) (PubMed).

Target Details for PPOX

Target: PPOX (Protoporphyrinogen Oxidase (PPOX))

Alternative Name: PPOX (PPOX Products)

Background: Full Gene Name: protoporphyrinogen oxidase
Synonyms: MGC8485,PPO,V290M,VP

Gene ID: 5498

Pathways: Synaptic Membrane, Feeding Behaviour