LLGL2 antibody (AA 101-199)

Catalog No. ABIN561680

Product Details anti-LLGL2 Antibody

Target: LLGL2 (Lethal Giant Larvae Homolog 2 (LLGL2))

Binding Specificity: AA 101-199

Reactivity: Human

Host: Mouse

Clonality: Monoclonal

Conjugate: This LLGL2 antibody is un-conjugated

Application: Western Blotting (WB), ELISA, Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))

Purpose: Mouse monoclonal antibody raised against a partial recombinant LLGL2.

Sequence: SLKVKGGASE LQEDESFTLR GPPGAAPSAT QITVVLPHSS CELLYLGTES GNVFVVQLPA FRALEDRTIS SDAVLQRLPE EARHRRVFEM VEALQEHPR

Cross-Reactivity: Human

Characteristics: Antibody Reactive Against Recombinant Protein.

Immunogen: LLGL2 (NP_004515, 101 a.a. ~ 199 a.a) partial recombinant protein with GST tag. MW of the GST tag alone is 26 KDa.

Clone: 4G2

Isotype: IgG2a

Application Details

Application Notes: Optimal working dilution should be determined by the investigator.

Restrictions: For Research Use only

Handling

Buffer: In 1x PBS, pH 7.4

Handling Advice: Aliquot to avoid repeated freezing and thawing.

Storage: -20 °C

Storage Comment: Store at -20°C or lower. Aliquot to avoid repeated freezing and thawing.

References for anti-LLGL2 antibody (ABIN561680)

Dong, Zhang, Liu, Chen, Huang, Austin, Celotto, Jiang, Palladino, Jiang, Hammond, Hong: "A conserved polybasic domain mediates plasma membrane targeting of Lgl and its regulation by hypoxia." in: The Journal of cell biology, Vol. 211, Issue 2, pp. 273-86, (2015) (PubMed).

Patil, Bennett, Mahajan, Bronner: "Distinguishing Barrett gastric foveolar dysplasia from reactive cardiac mucosa in gastroesophageal reflux disease." in: Human pathology, Vol. 44, Issue 6, pp. 1146-53, (2013) (PubMed).

Norman, Wisniewska, Lawrenson, Garcia-Miranda, Tada, Kajita, Mano, Ishikawa, Ikegawa, Shimada, Fujita: "Loss of Scribble causes cell competition in mammalian cells." in: Journal of cell science, Vol. 125, Issue Pt 1, pp. 59-66, (2012) (PubMed).

Russ, Louderbough, Zarnescu, Schroeder: "Hugl1 and Hugl2 in mammary epithelial cells: polarity, proliferation, and differentiation." in: PLoS ONE, Vol. 7, Issue 10, pp. e47734, (2012) (PubMed).

Cong, Hirose, Harita, Yamashita, Mizuno, Hirano, Ohno: "ASPP2 regulates epithelial cell polarity through the PAR complex." in: Current biology : CB, Vol. 20, Issue 15, pp. 1408-14, (2010) (PubMed).

Tamori, Bialucha, Tian, Kajita, Huang, Norman, Harrison, Poulton, Ivanovitch, Disch, Liu, Deng, Fujita: "Involvement of Lgl and Mahjong/VprBP in cell competition." in: PLoS biology, Vol. 8, Issue 7, pp. e1000422, (2010) (PubMed).

Target Details for LLGL2

Target: LLGL2 (Lethal Giant Larvae Homolog 2 (LLGL2))

Alternative Name: LLGL2 (LLGL2 Products)

Synonyms: lgl-2 antibody, lgl2 antibody, hgl antibody, Lgl-2 antibody, cb521 antibody, llglh2 antibody, sb:cb521 antibody, wu:fc06g08 antibody, wu:fl37c09 antibody, zgc:55895 antibody, HGL antibody, LGL2 antibody, 9130006H11Rik antibody, Llglh2 antibody, RGD1560307 antibody, LLGL2, scribble cell polarity complex component L homeolog antibody, LLGL2, scribble cell polarity complex component antibody, lethal giant larvae homolog 2 (Drosophila) antibody, llgl2.L antibody, llgl2 antibody, LLGL2 antibody, Llgl2 antibody

Background: Full Gene Name: lethal giant larvae homolog 2 (Drosophila)
Synonyms: HGL,LGL2

Gene ID: 3993

NCBI Accession: NM_004524

Pathways: WNT Signaling