ATRX antibody (AA 2311-2492)
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- Target See all ATRX Antibodies
- ATRX (helicase 2, X-linked (ATRX))
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Binding Specificity
- AA 2311-2492
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Reactivity
- Human
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Host
- Mouse
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Clonality
- Monoclonal
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Conjugate
- This ATRX antibody is un-conjugated
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Application
- ELISA
- Purpose
- ATRX Antibody
- Purification
- Purified antibody
- Immunogen
- Purified recombinant fragment of human ATRX (AA: 2311-2492) expressed in E. Coli.
- Clone
- 8B2H9
- Isotype
- IgG1
- Top Product
- Discover our top product ATRX Primary Antibody
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- Application Notes
- ELISA: 1/10000
- Restrictions
- For Research Use only
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- Format
- Liquid
- Buffer
- Purified antibody in PBS with 0.05 % sodium azide.
- Preservative
- Sodium azide
- Precaution of Use
- This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
- Storage
- 4 °C,-20 °C
- Storage Comment
- Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles.
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- Target
- ATRX (helicase 2, X-linked (ATRX))
- Alternative Name
- ATRX (ATRX Products)
- Background
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Description: The protein encoded by this gene contains an ATPase/helicase domain, and thus it belongs to the SWI/SNF family of chromatin remodeling proteins. This protein is found to undergo cell cycle-dependent phosphorylation, which regulates its nuclear matrix and chromatin association, and suggests its involvement in the gene regulation at interphase and chromosomal segregation in mitosis. Mutations in this gene are associated with an X-linked mental retardation (XLMR) syndrome most often accompanied by alpha-thalassemia (ATRX) syndrome. These mutations have been shown to cause diverse changes in the pattern of DNA methylation, which may provide a link between chromatin remodeling, DNA methylation, and gene expression in developmental processes. Multiple alternatively spliced transcript variants encoding distinct isoforms have been reported.
Aliases: JMS, SHS, XH2, XNP, ATR2, SFM1, MRX52, RAD54, MRXHF1, RAD54L, ZNF-HX
- Molecular Weight
- 282.5kDa
- Gene ID
- 546
- HGNC
- 546
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