SLAMF7 antibody (AA 23-226)

Catalog No. ABIN5611285

Product Details anti-SLAMF7 Antibody

Target: SLAMF7 (SLAM Family Member 7 (SLAMF7))

Binding Specificity: AA 23-226

Reactivity: Human

Host: Mouse

Clonality: Monoclonal

Conjugate: This SLAMF7 antibody is un-conjugated

Application: ELISA, Immunohistochemistry (IHC), Flow Cytometry (FACS)

Purpose: CD319 Antibody

Purification: Purified antibody

Immunogen: Purified recombinant fragment of human CD319 (AA: 23-226) expressed in E. Coli.

Clone: 5G5A4

Isotype: IgG1

Application Details

Application Notes:

ELISA: 1/10000

FCM: 1/200 - 1/400

Restrictions: For Research Use only

Handling

Format: Liquid

Buffer: Purified antibody in PBS with 0.05 % sodium azide.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: 4 °C,-20 °C

Storage Comment: Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles.

Target Details for SLAMF7

Target: SLAMF7 (SLAM Family Member 7 (SLAMF7))

Alternative Name: CD319 (SLAMF7 Products)

Synonyms: RGD1560190 antibody, SLAMF7 antibody, slaf7 antibody, 19A antibody, CD319 antibody, CRACC antibody, CS1 antibody, 19A24 antibody, 4930560D03Rik antibody, SLAM family member 7 antibody, Slamf7 antibody, SLAMF7 antibody, slaf7 antibody

Background:

Description: "Self-ligand receptor of the signaling lymphocytic activation molecule (SLAM) family. SLAM receptors triggered by homo- or heterotypic cell-cell interactions are modulating the activation and differentiation of a wide variety of immune cells and thus are involved in the regulation and interconnection of both innate and adaptive immune response. Activities are controlled by presence or absence of small cytoplasmic adapter proteins, SH2D1A/SAP and/or SH2D1B/EAT-2. Isoform 1 mediates NK cell activation through a SH2D1A-independent extracellular signal-regulated ERK-mediated pathway (PubMed:11698418). Positively regulates NK cell functions by a mechanism dependent on phosphorylated SH2D1B. Downstream signaling implicates PLCG1, PLCG2 and PI3K (PubMed:16339536). In addition to heterotypic NK cells-target cells interactions also homotypic interactions between NK cells may contribute to activation. However, in the absence of SH2D1B, inhibits NK cell function. Acts also inhibitory in T-cells (By similarity). May play a role in lymphocyte adhesion (PubMed:11802771). In LPS-activated monocytes negatively regulates production of proinflammatory cytokines (PubMed:23695528).
Isoform 3 does not mediate any NK cell activation."

Aliases: SLAMF7, 19A, CS1, CRACC

Molecular Weight: 37.4kDa

Gene ID: 57823

HGNC: 57823

UniProt: Q9NQ25