APAF1 antibody (AA 1138-1237)
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- Target See all APAF1 Antibodies
- APAF1 (Apoptotic Peptidase Activating Factor 1 (APAF1))
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Binding Specificity
- AA 1138-1237
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Reactivity
- Human
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Host
- Mouse
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Clonality
- Monoclonal
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Conjugate
- This APAF1 antibody is un-conjugated
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Application
- ELISA, Immunocytochemistry (ICC), Flow Cytometry (FACS)
- Purpose
- APAF1 Antibody
- Purification
- Purified antibody
- Immunogen
- Purified recombinant fragment of human APAF1 (AA: 1138-1237) expressed in E. Coli.
- Clone
- 2H9A1
- Isotype
- IgG2b
- Top Product
- Discover our top product APAF1 Primary Antibody
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- Application Notes
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ELISA: 1/10000
FCM: 1/200 - 1/400
ICC: 1/100 - 1/500
- Restrictions
- For Research Use only
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- Format
- Liquid
- Buffer
- Purified antibody in PBS with 0.05 % sodium azide.
- Preservative
- Sodium azide
- Precaution of Use
- This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
- Storage
- 4 °C,-20 °C
- Storage Comment
- Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles.
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- Target
- APAF1 (Apoptotic Peptidase Activating Factor 1 (APAF1))
- Alternative Name
- APAF1 (APAF1 Products)
- Background
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Description: This gene encodes a cytoplasmic protein that initiates apoptosis. This protein contains several copies of the WD-40 domain, a caspase recruitment domain (CARD), and an ATPase domain (NB-ARC). Upon binding cytochrome c and dATP, this protein forms an oligomeric apoptosome. The apoptosome binds and cleaves caspase 9 preproprotein, releasing its mature, activated form. Activated caspase 9 stimulates the subsequent caspase cascade that commits the cell to apoptosis. Alternative splicing results in several transcript variants encoding different isoforms.
Aliases: CED4, APAF-1
- Molecular Weight
- 141.8kDa
- Gene ID
- 317
- HGNC
- 317
- Pathways
- p53 Signaling, Apoptosis, Caspase Cascade in Apoptosis, Tube Formation, Positive Regulation of Endopeptidase Activity
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