Metabotropic Glutamate Receptor 1 antibody (AA 387-486)

Catalog No. ABIN5611175

Product Details anti-Metabotropic Glutamate Receptor 1 Antibody

Target: Metabotropic Glutamate Receptor 1 (GRM1) (Glutamate Receptor, Metabotropic 1 (GRM1))

Binding Specificity: AA 387-486

Reactivity: Human

Host: Mouse

Clonality: Monoclonal

Conjugate: This Metabotropic Glutamate Receptor 1 antibody is un-conjugated

Application: ELISA

Purpose: GRM1 Antibody

Purification: Purified antibody

Immunogen: Purified recombinant fragment of human GRM1 (AA: 387-486) expressed in E. Coli.

Clone: 5E12D8

Isotype: IgG1

Application Details

Application Notes: ELISA: 1/10000

Restrictions: For Research Use only

Handling

Format: Liquid

Buffer: Purified antibody in PBS with 0.05 % sodium azide.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: 4 °C,-20 °C

Storage Comment: Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles.

Target Details for Metabotropic Glutamate Receptor 1

Target: Metabotropic Glutamate Receptor 1 (GRM1) (Glutamate Receptor, Metabotropic 1 (GRM1))

Alternative Name: GRM1 (GRM1 Products)

Background:

Description: This gene encodes a metabotropic glutamate receptor that functions by activating phospholipase C. L-glutamate is the major excitatory neurotransmitter in the central nervous system and activates both ionotropic and metabotropic glutamate receptors. Glutamatergic neurotransmission is involved in most aspects of normal brain function and can be perturbed in many neuropathologic conditions. The canonical alpha isoform of the encoded protein is a disulfide-linked homodimer whose activity is mediated by a G-protein-coupled phosphatidylinositol-calcium second messenger system. This gene may be associated with many disease states, including schizophrenia, bipolar disorder, depression, and breast cancer. Alternative splicing results in multiple transcript variants encoding different isoforms.

Aliases: MGLU1, GPRC1A, MGLUR1, SCAR13, PPP1R85

Molecular Weight: 132.4kDa

Gene ID: 2911

HGNC: 2911