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IGHM antibody (AA 310-452)

IGHM Reactivity: Human IHC, WB, FACS, ELISA, ICC, Neut Host: Mouse Monoclonal 8B9D3 unconjugated
Catalog No. ABIN5611170
  • Target See all IGHM products
    IGHM (Immunoglobulin Heavy Constant mu (IGHM))
    Binding Specificity
    • 4
    • 2
    • 2
    • 1
    • 1
    AA 310-452
    Reactivity
    • 25
    • 1
    • 1
    Human
    Host
    • 13
    • 12
    Mouse
    Clonality
    • 16
    • 9
    Monoclonal
    Conjugate
    • 21
    • 1
    • 1
    • 1
    • 1
    This IGHM antibody is un-conjugated
    Application
    • 12
    • 11
    • 10
    • 7
    • 7
    • 7
    • 6
    • 4
    • 2
    • 1
    Immunohistochemistry (IHC), Western Blotting (WB), Flow Cytometry (FACS), ELISA, Immunocytochemistry (ICC), Neutralization (Neut)
    Purification
    purified
    Immunogen
    Purified recombinant fragment of human IGHM (AA: 310-452) expressed in E. coli.
    Clone
    8B9D3
    Isotype
    IgG1
  • Application Notes
    ELISA: 1:10000, WB: 1:200 - 1:500, ICC: N/A, FCM: 1:200 - 1:400, IHC: 1:200 - 1:1000
    Restrictions
    For Research Use only
  • Format
    Liquid
    Buffer
    Purified antibody in PBS with 0.05 % sodium azide
    Preservative
    Sodium azide
    Precaution of Use
    This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
    Storage
    4 °C/-20 °C
    Storage Comment
    4°C, -20°C for long term storage
  • Target
    IGHM (Immunoglobulin Heavy Constant mu (IGHM))
    Alternative Name
    IGHM (IGHM Products)
    Synonyms
    AI326478 antibody, Igh-6 antibody, Igh-M antibody, Igh6 antibody, Igm antibody, muH antibody, ighm1 antibody, wu:fj14a08 antibody, zgc:101769 antibody, AGM1 antibody, MU antibody, VH antibody, immunoglobulin heavy constant mu antibody, Ighm antibody, ighm antibody, IGHM antibody
    Background

    Description: Immunoglobulins (Ig) are the antigen recognition molecules of B cells. An Ig molecule is made up of 2 identical heavy chains and 2 identical light chains (see MIM 147200) joined by disulfide bonds so that each heavy chain is linked to a light chain and the 2 heavy chains are linked together. Each Ig heavy chain has an N-terminal variable (V) region containing the antigen-binding site and a C-terminal constant (C) region, encoded by an individual C region gene, that determines the isotype of the antibody and provides effector or signaling functions. The heavy chain V region is encoded by 1 each of 3 types of genes: V genes (see MIM 147070), joining (J) genes (see MIM 147010), and diversity (D) genes (see MIM 146910). The C region genes are clustered downstream of the V region genes within the heavy chain locus on chromosome 14. The IGHM gene encodes the C region of the mu heavy chain, which defines the IgM isotype. Naive B cells express the transmembrane forms of IgM and IgD (see IGHD, MIM 1471770) on their surface. During an antibody response, activated B cells can switch to the expression of individual downstream heavy chain C region genes by a process of somatic recombination known as isotype switching. In addition, secreted Ig forms that act as antibodies can be produced by alternative RNA processing of the heavy chain C region sequences. Although the membrane forms of all Ig isotypes are monomeric, secreted IgM forms pentamers, and occasionally hexamers, in plasma (summary by Janeway et al., 2005).

    Aliases: MU, VH, AGM1

    Molecular Weight
    49.3 kDa
    Gene ID
    3507
    HGNC
    3507
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