GRM8 antibody (AA 440-583)

Catalog No. ABIN5611162

Product Details anti-GRM8 Antibody

Target: GRM8 (Glutamate Receptor, Metabotropic 8 (GRM8))

Binding Specificity: AA 440-583

Reactivity: Human

Host: Mouse

Clonality: Monoclonal

Conjugate: This GRM8 antibody is un-conjugated

Application: Western Blotting (WB), ELISA, Flow Cytometry (FACS)

Purpose: GRM8 Antibody

Purification: Purified antibody

Immunogen: Purified recombinant fragment of human GRM8 (AA: 440-583) expressed in E. Coli.

Clone: 4C1C1

Isotype: IgG1

Application Details

Application Notes:

ELISA: 1/10000

FCM: 1/200 - 1/400

Restrictions: For Research Use only

Handling

Format: Liquid

Buffer: Purified antibody in PBS with 0.05 % sodium azide.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: 4 °C,-20 °C

Storage Comment: Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles.

Target Details for GRM8

Target: GRM8 (Glutamate Receptor, Metabotropic 8 (GRM8))

Alternative Name: GRM8 (GRM8 Products)

Synonyms: mGluR8 antibody, GRM8 antibody, MGLUR8 antibody, GLUR8 antibody, GPRC1H antibody, mGlu8 antibody, A230002O04 antibody, Gprc1h antibody, Glur8 antibody, Mglur8 antibody, mGluR8b antibody, mGlur antibody, glutamate metabotropic receptor 8 antibody, metabotropic glutamate receptor 8 antibody, glutamate receptor, metabotropic 8 antibody, GRM8 antibody, MGLUR8 antibody, LOAG_14062 antibody, Grm8 antibody

Background:

Description: L-glutamate is the major excitatory neurotransmitter in the central nervous system and activates both ionotropic and metabotropic glutamate receptors. Glutamatergic neurotransmission is involved in most aspects of normal brain function and can be perturbed in many neuropathologic conditions. The metabotropic glutamate receptors are a family of G protein-coupled receptors, that have been divided into 3 groups on the basis of sequence homology, putative signal transduction mechanisms, and pharmacologic properties. Group I includes GRM1 and GRM5 and these receptors have been shown to activate phospholipase C. Group II includes GRM2 and GRM3 while Group III includes GRM4, GRM6, GRM7 and GRM8. Group II and III receptors are linked to the inhibition of the cyclic AMP cascade but differ in their agonist selectivities. Alternatively spliced transcript variants encoding different isoforms have been described for this gene.

Aliases: GLUR8, mGlu8, GPRC1H, MGLUR8

Molecular Weight: 101.7kDa

Gene ID: 2918

HGNC: 2918

UniProt: O00222

Pathways: cAMP Metabolic Process, Synaptic Membrane