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BCR antibody (AA 139-280)

BCR Reactivity: Human WB, ELISA, FACS Host: Mouse Monoclonal 1E11G12 unconjugated
Catalog No. ABIN5611129
  • Target See all BCR Antibodies
    BCR (Breakpoint Cluster Region (BCR))
    Binding Specificity
    • 28
    • 16
    • 8
    • 4
    • 4
    • 3
    • 3
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    AA 139-280
    Reactivity
    • 92
    • 52
    • 26
    • 6
    • 4
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    Human
    Host
    • 86
    • 9
    • 4
    Mouse
    Clonality
    • 89
    • 10
    Monoclonal
    Conjugate
    • 55
    • 6
    • 3
    • 3
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    This BCR antibody is un-conjugated
    Application
    • 64
    • 35
    • 34
    • 26
    • 26
    • 26
    • 18
    • 16
    • 9
    • 6
    • 5
    • 4
    • 3
    • 2
    • 1
    • 1
    Western Blotting (WB), ELISA, Flow Cytometry (FACS)
    Purpose
    BCR Antibody
    Purification
    Purified antibody
    Immunogen
    Purified recombinant fragment of human BCR (AA: 139-280) expressed in E. Coli.
    Clone
    1E11G12
    Isotype
    IgG1
  • Application Notes

    ELISA: 1/10000

    FCM: 1/200 - 1/400

    Restrictions
    For Research Use only
  • Format
    Liquid
    Buffer
    Purified antibody in PBS with 0.05 % sodium azide.
    Preservative
    Sodium azide
    Precaution of Use
    This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
    Storage
    4 °C,-20 °C
    Storage Comment
    Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles.
  • Target
    BCR (Breakpoint Cluster Region (BCR))
    Alternative Name
    BCR (BCR Products)
    Background

    Description: A reciprocal translocation between chromosomes 22 and 9 produces the Philadelphia chromosome, which is often found in patients with chronic myelogenous leukemia. The chromosome 22 breakpoint for this translocation is located within the BCR gene. The translocation produces a fusion protein which is encoded by sequence from both BCR and ABL, the gene at the chromosome 9 breakpoint. Although the BCR-ABL fusion protein has been extensively studied, the function of the normal BCR gene product is not clear. The protein has serine/threonine kinase activity and is a GTPase-activating protein for p21rac. Two transcript variants encoding different isoforms have been found for this gene.

    Aliases: ALL, CML, PHL, BCR1, D22S11, D22S662

    Molecular Weight
    142.8kDa
    Gene ID
    613
    HGNC
    613
    UniProt
    P11274
    Pathways
    Regulation of Leukocyte Mediated Immunity, Platelet-derived growth Factor Receptor Signaling
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