BCR antibody (AA 139-280)
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- Target See all BCR Antibodies
- BCR (Breakpoint Cluster Region (BCR))
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Binding Specificity
- AA 139-280
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Reactivity
- Human
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Host
- Mouse
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Clonality
- Monoclonal
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Conjugate
- This BCR antibody is un-conjugated
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Application
- Western Blotting (WB), ELISA, Flow Cytometry (FACS)
- Purpose
- BCR Antibody
- Purification
- Purified antibody
- Immunogen
- Purified recombinant fragment of human BCR (AA: 139-280) expressed in E. Coli.
- Clone
- 1E11G12
- Isotype
- IgG1
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anti-Breakpoint Cluster Region (BCR) (AA 182-280) antibody
BCR Reactivity: Human WB, ELISA, IF, PLA Host: Mouse Monoclonal 2E5 unconjugated
anti-Breakpoint Cluster Region (BCR) (pTyr360) antibodyBCR Reactivity: Human, Mouse, Rat WB, ELISA, IHC, IF, ICC Host: Rabbit Polyclonal unconjugated
anti-Breakpoint Cluster Region (BCR) (pTyr177) antibodyBCR Reactivity: Human, Mouse WB, ELISA, IF, ICC Host: Rabbit Polyclonal unconjugated
anti-Breakpoint Cluster Region (BCR) (AA 1-300) antibodyBCR Reactivity: Human WB, IHC Host: Rabbit Polyclonal unconjugated
anti-Breakpoint Cluster Region (BCR) (N-Term) antibodyBCR Reactivity: Human, Mouse WB, ELISA, IF, ICC Host: Rabbit Polyclonal unconjugated
anti-Breakpoint Cluster Region (BCR) (AA 1-1076) antibodyBCR Reactivity: Human WB, PLA Host: Rabbit Polyclonal unconjugated
anti-Breakpoint Cluster Region (BCR) (AA 331-380), (pTyr360) antibodyBCR Reactivity: Human, Mouse WB, ELISA, IHC, IF Host: Rabbit Polyclonal unconjugated
anti-Breakpoint Cluster Region (BCR) (pTyr177) antibodyBCR Reactivity: Human WB, ELISA, FACS, IF (cc), IF (p), IHC (p), IHC (fro) Host: Rabbit Polyclonal unconjugated
anti-Breakpoint Cluster Region (BCR) (pTyr360) antibodyBCR Reactivity: Human WB, ELISA Host: Rabbit Polyclonal unconjugated
anti-Breakpoint Cluster Region (BCR) (Ser178) antibodyBCR Reactivity: Human, Mouse WB, ELISA, IHC Host: Rabbit Polyclonal unconjugated
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- Application Notes
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ELISA: 1/10000
FCM: 1/200 - 1/400
- Restrictions
- For Research Use only
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- Format
- Liquid
- Buffer
- Purified antibody in PBS with 0.05 % sodium azide.
- Preservative
- Sodium azide
- Precaution of Use
- This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
- Storage
- 4 °C,-20 °C
- Storage Comment
- Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles.
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- Target
- BCR (Breakpoint Cluster Region (BCR))
- Alternative Name
- BCR (BCR Products)
- Background
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Description: A reciprocal translocation between chromosomes 22 and 9 produces the Philadelphia chromosome, which is often found in patients with chronic myelogenous leukemia. The chromosome 22 breakpoint for this translocation is located within the BCR gene. The translocation produces a fusion protein which is encoded by sequence from both BCR and ABL, the gene at the chromosome 9 breakpoint. Although the BCR-ABL fusion protein has been extensively studied, the function of the normal BCR gene product is not clear. The protein has serine/threonine kinase activity and is a GTPase-activating protein for p21rac. Two transcript variants encoding different isoforms have been found for this gene.
Aliases: ALL, CML, PHL, BCR1, D22S11, D22S662
- Molecular Weight
- 142.8kDa
- Gene ID
- 613
- HGNC
- 613
- UniProt
- P11274
- Pathways
- Regulation of Leukocyte Mediated Immunity, Platelet-derived growth Factor Receptor Signaling
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