Adenosine A2a Receptor antibody (AA 274-412)

Catalog No. ABIN5611128

Product Details anti-Adenosine A2a Receptor Antibody

Target: Adenosine A2a Receptor (ADORA2A)

Binding Specificity: AA 274-412

Reactivity: Human

Host: Mouse

Clonality: Monoclonal

Conjugate: This Adenosine A2a Receptor antibody is un-conjugated

Application: ELISA, Flow Cytometry (FACS), Immunocytochemistry (ICC)

Purpose: ADORA2A Antibody

Purification: Purified antibody

Immunogen: Purified recombinant fragment of human ADORA2A (AA: 274-412) expressed in E. Coli.

Clone: 6A6G11

Isotype: IgG2a

Application Details

Application Notes:

ELISA: 1/10000

FCM: 1/200 - 1/400

ICC: 1/100 - 1/500

Restrictions: For Research Use only

Handling

Format: Liquid

Buffer: Purified antibody in PBS with 0.05 % sodium azide.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: 4 °C,-20 °C

Storage Comment: Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles.

Target Details for Adenosine A2a Receptor

Target: Adenosine A2a Receptor (ADORA2A)

Alternative Name: ADORA2A (ADORA2A Products)

Synonyms: ADORA2A antibody, adora2a.1 antibody, zgc:194773 antibody, A2aR antibody, ADORA2 antibody, RDC8 antibody, A2AAR antibody, AA2AR antibody, A2ar antibody, ADENO antibody, Adora2l1 antibody, adora2a.2 antibody, zgc:193802 antibody, zgc:193822 antibody, adenosine A2a receptor antibody, adenosine A2a receptor a antibody, adenosine A2a receptor L homeolog antibody, adenosine A2a receptor b antibody, ADORA2A antibody, Adora2a antibody, adora2aa antibody, adora2a.L antibody, adora2a antibody, adora2ab antibody

Background:

Description: This gene encodes a member of the guanine nucleotide-binding protein (G protein)-coupled receptor (GPCR) superfamily, which is subdivided into classes and subtypes. The receptors are seven-pass transmembrane proteins that respond to extracellular cues and activate intracellular signal transduction pathways. This protein, an adenosine receptor of A2A subtype, uses adenosine as the preferred endogenous agonist and preferentially interacts with the G(s) and G(olf) family of G proteins to increase intracellular cAMP levels. It plays an important role in many biological functions, such as cardiac rhythm and circulation, cerebral and renal blood flow, immune function, pain regulation, and sleep. It has been implicated in pathophysiological conditions such as inflammatory diseases and neurodegenerative disorders. Alternative splicing results in multiple transcript variants. A read-through transcript composed of the upstream SPECC1L (sperm antigen with calponin homology and coiled-coil domains 1-like) and ADORA2A (adenosine A2a receptor) gene sequence has been identified, but it is thought to be non-coding.

Aliases: A2aR, RDC8, ADORA2

Molecular Weight: 44.7kDa

Gene ID: 135

HGNC: 135

UniProt: P29274

Pathways: Neurotrophin Signaling Pathway, cAMP Metabolic Process, Synaptic Membrane, Feeding Behaviour, Cancer Immune Checkpoints