Filamin A antibody (AA 1-838)

Catalog No. ABIN560922

Product Details anti-Filamin A Antibody

Target: Filamin A (FLNA) (Filamin A, alpha (FLNA))

Binding Specificity: AA 1-838

Reactivity: Human

Host: Mouse

Clonality: Monoclonal

Conjugate: This Filamin A antibody is un-conjugated

Application: Western Blotting (WB), ELISA, Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Proximity Ligation Assay (PLA)

Purpose: Mouse monoclonal antibody raised against a full length recombinant FLNA.

Sequence: MPSGKVAQPT ITDNKDGTVT VRYAPSEAGL HEMDIRYDNM HIPGSPLQFY VDYVNCGHVT AYGPGLTHGV VNKPATFTVN TKDAGEGGLS LAIEGPSKAE ISCTDNQDGT CSVSYLPVLP GDYSILVKYN EQHVPGSPFT ARVTGDDSMR MSHLKVGSAA DIPINISETD LSLLTATVVP PSGREEPCLL KRLRNGHVGI SFVPKETGEH LVHVKKNGQH VASSPIPVVI SQSEIGDASR VRVSGQGLHE GHTFEPAEFI IDTRDAGYGG LSLSIEGPSK VDINTEDLED GTCRVTYCPT EPGNYIINIK FADQHVPGSP FSVKVTGEGR VKESITRRRR APSVANVGSH CDLSLKIPEI SIQDMTAQVT SPSGKTHEAE IVEGENHTYC IRFVPAEMGT HTVSVKYKGQ HVPGSPFQFT VGPLGEGGAH KVRAGGPGLE RAEAGVPAEF SIWTREAGAG GLAIAVEGPS KAEISFEDRK DGSCGVAYVV QEPGDYEVSV KFNEEHIPDS PFVVPVASPS GDARRLTVSS LQESGLKVNQ PASFAVSLNG AKGAIDAKVH SPSGALEECY VTEIDQDKYA VRFIPRENGV YLIDVKFNGT HIPGSPFKIR VGEPGHGGDP GLVSAYGAGL EGGVTGNPAE FVVNTSNAGA GALSVTIDGP SKVKMDCQEC PEGYRVTYTP MAPGSYLISI KYGGPYHIGG SPFKAKVTGP RLVSNHSLHE TSSVFVDSLT KATCAPQHGA PGPGPADASK VVAKGLGLSK AYVGQKSSFT VDCSKAGNNM LLVGVHGPRT PCEEILVKHV GSRLYSVSYL LKDKGEYTLV VKWGDEHIPG SPYRVVVP

Cross-Reactivity: Human

Characteristics: Antibody Reactive Against Recombinant Protein.

Immunogen: FLNA (AAH14654, 1 a.a. ~ 838 a.a) full-length recombinant protein with GST tag. MW of the GST tag alone is 26 KDa.

Clone: 4E10-1B2

Isotype: IgG1

Application Details

Application Notes: Optimal working dilution should be determined by the investigator.

Restrictions: For Research Use only

Handling

Buffer: In 1x PBS, pH 7.4

Handling Advice: Aliquot to avoid repeated freezing and thawing.

Storage: -20 °C

Storage Comment: Store at -20°C or lower. Aliquot to avoid repeated freezing and thawing.

References for anti-Filamin A antibody (ABIN560922)

Mingione, Verdelli, Ferrero, Vaira, Guarnieri, Scillitani, Vicentini, Balza, Beretta, Terranegra, Vezzoli, Soldati, Corbetta: "Filamin A is reduced and contributes to the CASR sensitivity in human parathyroid tumors." in: Journal of molecular endocrinology, Vol. 58, Issue 2, pp. 91-103, (2016) (PubMed).

Parrini, Mei, Pisanti, Catarzi, Pucatti, Bianchini, Mascalchi, Bertini, Morrone, Cavaliere, Guerrini: "Familial periventricular nodular heterotopia, epilepsy and Melnick-Needles Syndrome caused by a single FLNA mutation with combined gain-of-function and loss-of-function effects." in: Journal of medical genetics, Vol. 52, Issue 6, pp. 405-12, (2015) (PubMed).

Bézie, Picarda, Tesson, Renaudin, Durand, Ménoret, Mérieau, Chiffoleau, Guillonneau, Caron, Anegon: "Fibrinogen-like protein 2/fibroleukin induces long-term allograft survival in a rat model through regulatory B cells." in: PLoS ONE, Vol. 10, Issue 3, pp. e0119686, (2015) (PubMed).

Peverelli, Giardino, Treppiedi, Vitali, Cambiaghi, Locatelli, Lasio, Spada, Lania, Mantovani: "Filamin A (FLNA) plays an essential role in somatostatin receptor 2 (SST2) signaling and stabilization after agonist stimulation in human and rat somatotroph tumor cells." in: Endocrinology, Vol. 155, Issue 8, pp. 2932-41, (2014) (PubMed).

Oegema, Hulst, Theuns-Valks, van Unen, Schot, Mancini, Schipper, de Wit, Sibbles, de Coo, Nanninga, Hofstra, Halley, Brooks: "Novel no-stop FLNA mutation causes multi-organ involvement in males." in: American journal of medical genetics. Part A, Vol. 161A, Issue 9, pp. 2376-84, (2013) (PubMed).

Sakane, Alamir Mahmoud Abdallah, Nakano, Honda, Kitamura, Imoto, Matsushita, Sasaki: "Junctional Rab13-binding protein (JRAB) regulates cell spreading via filamins." in: Genes to cells : devoted to molecular & cellular mechanisms, Vol. 18, Issue 9, pp. 810-22, (2013) (PubMed).

Peverelli, Mantovani, Vitali, Elli, Olgiati, Ferrero, Laws, Della Mina, Villa, Beck-Peccoz, Spada, Lania: "Filamin-A is essential for dopamine d2 receptor expression and signaling in tumorous lactotrophs." in: The Journal of clinical endocrinology and metabolism, Vol. 97, Issue 3, pp. 967-77, (2012) (PubMed).

Valente, Logan, Mougou-Zerelli, Lee, Silhavy, Brancati, Iannicelli, Travaglini, Romani, Illi, Adams, Szymanska, Mazzotta, Lee, Tolentino, Swistun, Salpietro, Fede, Gabriel, Russ, Cibulskis, Sougnez et al.: "Mutations in TMEM216 perturb ciliogenesis and cause Joubert, Meckel and related syndromes. ..." in: Nature genetics, Vol. 42, Issue 7, pp. 619-25, (2010) (PubMed).

Target Details for Filamin A

Target: Filamin A (FLNA) (Filamin A, alpha (FLNA))

Alternative Name: FLNA (FLNA Products)

Background: Full Gene Name: filamin A, alpha (actin binding protein 280)
Synonyms: ABP-280,ABPX,DKFZp434P031,FLN,FLN1,FMD,MNS,NHBP,OPD,OPD1,OPD2

Gene ID: 2316

Pathways: TCR Signaling, Maintenance of Protein Location