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DYRK1A antibody (AA 674-763)

DYRK1A Reactivity: Human WB, ELISA Host: Mouse Monoclonal 7D10 unconjugated
Catalog No. ABIN560675
  • Target See all DYRK1A Antibodies
    DYRK1A (Dual-Specificity tyrosine-(Y)-phosphorylation Regulated Kinase 1A (DYRK1A))
    Binding Specificity
    • 15
    • 10
    • 9
    • 8
    • 8
    • 7
    • 5
    • 2
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    AA 674-763
    Reactivity
    • 73
    • 30
    • 22
    • 6
    • 5
    • 4
    • 4
    • 4
    • 4
    • 2
    • 2
    • 2
    • 2
    • 1
    Human
    Host
    • 68
    • 3
    • 2
    • 1
    Mouse
    Clonality
    • 71
    • 3
    Monoclonal
    Conjugate
    • 38
    • 6
    • 6
    • 5
    • 4
    • 4
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    This DYRK1A antibody is un-conjugated
    Application
    • 74
    • 42
    • 14
    • 13
    • 13
    • 11
    • 8
    • 6
    • 6
    • 3
    • 2
    • 2
    • 1
    Western Blotting (WB), ELISA
    Purpose
    Mouse monoclonal antibody raised against a partial recombinant DYRK1A.
    Sequence
    NQGNQAYQNR PVAANTLDFG QNGAMDVNLT VYSNPRQETG IAGHPTYQFS ANTGPAHYMT EGHLTMRQGA DREESPMTGV CVQQSPVASS
    Cross-Reactivity
    Human, Mouse, Rat
    Characteristics
    Antibody Reactive Against Recombinant Protein.
    Immunogen
    DYRK1A (NP_001387, 674 a.a. ~ 763 a.a) partial recombinant protein with GST tag. MW of the GST tag alone is 26 KDa.
    Clone
    7D10
    Isotype
    IgG2b
  • Application Notes
    Optimal working dilution should be determined by the investigator.
    Restrictions
    For Research Use only
  • Buffer
    In 1x PBS, pH 7.4
    Handling Advice
    Aliquot to avoid repeated freezing and thawing.
    Storage
    -20 °C
    Storage Comment
    Store at -20°C or lower. Aliquot to avoid repeated freezing and thawing.
  • Rabaneda, Geribaldi-Doldán, Murillo-Carretero, Carrasco, Martínez-Salas, Verástegui, Castro: "Altered regulation of the Spry2/Dyrk1A/PP2A triad by homocysteine impairs neural progenitor cell proliferation." in: Biochimica et biophysica acta, Vol. 1863, Issue 12, pp. 3015-3026, (2016) (PubMed).

    Souchet, Latour, Gu, Daubigney, Paul, Delabar, Janel: "Molecular rescue of DYRK1A overexpression in cystathionine beta synthase-deficient mouse brain by enriched environment combined with voluntary exercise." in: Journal of molecular neuroscience : MN, Vol. 55, Issue 2, pp. 318-23, (2015) (PubMed).

    Thompson, Bhansali, Diebold, Cook, Stolzenburg, Casagrande, Besson, Leblond, Désiré, Malinge, Crispino: "DYRK1A controls the transition from proliferation to quiescence during lymphoid development by destabilizing Cyclin D3." in: The Journal of experimental medicine, Vol. 212, Issue 6, pp. 953-70, (2015) (PubMed).

    Najas, Arranz, Lochhead, Ashford, Oxley, Delabar, Cook, Barallobre, Arbonés: "DYRK1A-mediated Cyclin D1 Degradation in Neural Stem Cells Contributes to the Neurogenic Cortical Defects in Down Syndrome." in: EBioMedicine, Vol. 2, Issue 2, pp. 120-34, (2015) (PubMed).

    Blazek, Abeysekera, Li, Roper: "Rescue of the abnormal skeletal phenotype in Ts65Dn Down syndrome mice using genetic and therapeutic modulation of trisomic Dyrk1a." in: Human molecular genetics, Vol. 24, Issue 20, pp. 5687-96, (2015) (PubMed).

    Stringer, Abeysekera, Dria, Roper, Goodlett: "Low dose EGCG treatment beginning in adolescence does not improve cognitive impairment in a Down syndrome mouse model." in: Pharmacology, biochemistry, and behavior, Vol. 138, pp. 70-9, (2015) (PubMed).

    Fant, Durieu, Chicanne, Payrastre, Sbrissa, Shisheva, Limanton, Carreaux, Bazureau, Meijer: "cdc-like/dual-specificity tyrosine phosphorylation-regulated kinases inhibitor leucettine L41 induces mTOR-dependent autophagy: implication for Alzheimer's disease." in: Molecular pharmacology, Vol. 85, Issue 3, pp. 441-50, (2014) (PubMed).

    Hibaoui, Grad, Letourneau, Sailani, Dahoun, Santoni, Gimelli, Guipponi, Pelte, Béna, Antonarakis, Feki: "Modelling and rescuing neurodevelopmental defect of Down syndrome using induced pluripotent stem cells from monozygotic twins discordant for trisomy 21." in: EMBO molecular medicine, Vol. 6, Issue 2, pp. 259-77, (2014) (PubMed).

    Rachdi, Kariyawasam, Guez, Aïello, Arbonés, Janel, Delabar, Polak, Scharfmann: "Dyrk1a haploinsufficiency induces diabetes in mice through decreased pancreatic beta cell mass." in: Diabetologia, Vol. 57, Issue 5, pp. 960-9, (2014) (PubMed).

    García-Cerro, Martínez, Vidal, Corrales, Flórez, Vidal, Rueda, Arbonés, Martínez-Cué: "Overexpression of Dyrk1A is implicated in several cognitive, electrophysiological and neuromorphological alterations found in a mouse model of Down syndrome." in: PLoS ONE, Vol. 9, Issue 9, pp. e106572, (2014) (PubMed).

    Thomazeau, Lassalle, Iafrati, Souchet, Guedj, Janel, Chavis, Delabar, Manzoni: "Prefrontal deficits in a murine model overexpressing the down syndrome candidate gene dyrk1a." in: The Journal of neuroscience : the official journal of the Society for Neuroscience, Vol. 34, Issue 4, pp. 1138-47, (2014) (PubMed).

    Janel, Sarazin, Corlier, Corne, de Souza, Hamelin, Aka, Lagarde, Blehaut, Hindié, Rain, Arbones, Dubois, Potier, Bottlaender, Delabar: "Plasma DYRK1A as a novel risk factor for Alzheimer's disease." in: Translational psychiatry, Vol. 4, pp. e425, (2014) (PubMed).

    Grau, Arató, Fernández-Fernández, Valderrama, Sindreu, Fillat, Ferrer, de la Luna, Altafaj: "DYRK1A-mediated phosphorylation of GluN2A at Ser(1048) regulates the surface expression and channel activity of GluN1/GluN2A receptors." in: Frontiers in cellular neuroscience, Vol. 8, pp. 331, (2014) (PubMed).

    Planque, Dairou, Noll, Bui, Ripoll, Guedj, Delabar, Janel: "Mice deficient in cystathionine beta synthase display increased Dyrk1A and SAHH activities in brain." in: Journal of molecular neuroscience : MN, Vol. 50, Issue 1, pp. 1-6, (2013) (PubMed).

    Abekhoukh, Planque, Ripoll, Urbaniak, Paul, Delabar, Janel: "Dyrk1A, a serine/threonine kinase, is involved in ERK and Akt activation in the brain of hyperhomocysteinemic mice." in: Molecular neurobiology, Vol. 47, Issue 1, pp. 105-16, (2013) (PubMed).

    Altafaj, Martín, Ortiz-Abalia, Valderrama, Lao-Peregrín, Dierssen, Fillat: "Normalization of Dyrk1A expression by AAV2/1-shDyrk1A attenuates hippocampal-dependent defects in the Ts65Dn mouse model of Down syndrome." in: Neurobiology of disease, Vol. 52, pp. 117-27, (2013) (PubMed).

    Arque, Casanovas, Dierssen: "Dyrk1A is dynamically expressed on subsets of motor neurons and in the neuromuscular junction: possible role in Down syndrome." in: PLoS ONE, Vol. 8, Issue 1, pp. e54285, (2013) (PubMed).

    Tlili, Jacobs, de Koning, Mohamed, Bui, Dairou, Belin, Ducros, Dubois, Paul, Delabar, De Geest, Janel: "Hepatocyte-specific Dyrk1a gene transfer rescues plasma apolipoprotein A-I levels and aortic Akt/GSK3 pathways in hyperhomocysteinemic mice." in: Biochimica et biophysica acta, Vol. 1832, Issue 6, pp. 718-28, (2013) (PubMed).

    Laguna, Barallobre, Marchena, Mateus, Ramírez, Martínez-Cue, Delabar, Castelo-Branco, de la Villa, Arbonés: "Triplication of DYRK1A causes retinal structural and functional alterations in Down syndrome." in: Human molecular genetics, Vol. 22, Issue 14, pp. 2775-84, (2013) (PubMed).

    Stefos, Soppa, Dierssen, Becker: "NGF upregulates the plasminogen activation inhibitor-1 in neurons via the calcineurin/NFAT pathway and the Down syndrome-related proteins DYRK1A and RCAN1 attenuate this effect." in: PLoS ONE, Vol. 8, Issue 6, pp. e67470, (2013) (PubMed).

  • Target
    DYRK1A (Dual-Specificity tyrosine-(Y)-phosphorylation Regulated Kinase 1A (DYRK1A))
    Alternative Name
    DYRK1A (DYRK1A Products)
    Synonyms
    DYRK1A antibody, dyrk antibody, dyrk1 antibody, hp86 antibody, mnb antibody, mnbh antibody, DYRK antibody, DYRK1 antibody, HP86 antibody, MNB antibody, MNBH antibody, MRD7 antibody, 2310043O08Rik antibody, D16Ertd272e antibody, D16Ertd493e antibody, Dyrk antibody, ENSMUSG00000074897 antibody, Gm10783 antibody, Mnbh antibody, Mp86 antibody, mmb antibody, PSK47 antibody, dual specificity tyrosine phosphorylation regulated kinase 1A antibody, dual specificity tyrosine-(Y)-phosphorylation regulated kinase 1A antibody, dual-specificity tyrosine-(Y)-phosphorylation regulated kinase 1a antibody, dual specificity tyrosine-(Y)-phosphorylation regulated kinase 1A S homeolog antibody, DYRK1A antibody, dyrk1a antibody, Dyrk1a antibody, dyrk1a.S antibody
    Background
    Full Gene Name: dual-specificity tyrosine-(Y)-phosphorylation regulated kinase 1A
    Synonyms: DYRK,DYRK1,HP86,MNB,MNBH
    Gene ID
    1859
    NCBI Accession
    NM_001396
    Pathways
    Mitotic G1-G1/S Phases
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