Exportin 2 antibody (AA 872-971)

Catalog No. ABIN560494

Product Details anti-Exportin 2 Antibody

Target: Exportin 2 (CSE1L) (CSE1 Chromosome Segregation 1-Like (CSE1L))

Binding Specificity: AA 872-971

Reactivity: Human

Host: Mouse

Clonality: Monoclonal

Conjugate: This Exportin 2 antibody is un-conjugated

Application: Western Blotting (WB), ELISA, Immunofluorescence (IF), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))

Purpose: Mouse monoclonal antibody raised against a partial recombinant CSE1L.

Sequence: LIGLFELPED DTIPDEEHFI DIEDTPGYQT AFSQLAFAGK KEHDPVGQMV NNPKIHLAQS LHKLSTACPG RVPSMVSTSL NAEALQYLQG YLQAARVTLL

Cross-Reactivity: Human

Characteristics: Antibody Reactive Against Recombinant Protein.

Immunogen: CSE1L (NP_001307, 872 a.a. ~ 971 a.a) partial recombinant protein with GST tag. MW of the GST tag alone is 26 KDa.

Clone: 3D8

Isotype: IgG1

Application Details

Application Notes: Optimal working dilution should be determined by the investigator.

Restrictions: For Research Use only

Handling

Buffer: In 1x PBS, pH 7.4

Handling Advice: Aliquot to avoid repeated freezing and thawing.

Storage: -20 °C

Storage Comment: Store at -20°C or lower. Aliquot to avoid repeated freezing and thawing.

References for anti-Exportin 2 antibody (ABIN560494)

Luo, Qu, Kan, Cai: "The microRNA-451a/chromosome segregation 1-like axis suppresses cell proliferation, migration, and invasion and induces apoptosis in nasopharyngeal carcinoma." in: Bioengineered, Vol. 12, Issue 1, pp. 6967-6980, (2021) (PubMed).

Chin, Wu, Shih, Yeh, Lee, Shen, Yeh, Jiang, Tseng: "High expression of cytoplasmic phosphorylated CSE1L in malignant melanoma but not in benign nevi: phosphorylated CSE1L for the discrimination between melanoma and benign nevi." in: International journal of clinical and experimental pathology, Vol. 8, Issue 2, pp. 1393-401, (2015) (PubMed).

Lee, Shen, Shih, Chou, Tseng, Chin, Liu, Chen, Jiang: "Early decline in serum phospho-CSE1L levels in vemurafenib/sunitinib-treated melanoma and sorafenib/lapatinib-treated colorectal tumor xenografts." in: Journal of translational medicine, Vol. 13, pp. 191, (2015) (PubMed).

Okimoto, Sun, Fukuto, Horikoshi, Matsuda, Matsuda, Ikura, Ikura, Machida, Kurumizaka, Miyamoto, Oka, Yoneda, Kiuchi, Tashiro: "hCAS/CSE1L regulates RAD51 distribution and focus formation for homologous recombinational repair." in: Genes to cells : devoted to molecular & cellular mechanisms, Vol. 20, Issue 9, pp. 681-94, (2015) (PubMed).

Li, Yang, Pang, Chan, Zhou, Mao, Wang, Lau, Poon, Shi, Ng: "MIR-137 suppresses growth and invasion, is downregulated in oligodendroglial tumors and targets CSE1L." in: Brain pathology (Zurich, Switzerland), Vol. 23, Issue 4, pp. 426-39, (2013) (PubMed).

Jiang, Yeh, Tai, Chen, Lin, Su, Shen, Lee, Liao, Li, Lee, Chen, Yeh, Chang: "CSE1L modulates Ras-induced cancer cell invasion: correlation of K-Ras mutation and CSE1L expression in colorectal cancer progression." in: American journal of surgery, Vol. 206, Issue 3, pp. 418-27, (2013) (PubMed).

Chang, Tai, Su, Shen, Lin, Yeh, Yeh, Lin, Jiang: "The prognostic significance of nuclear CSE1L in urinary bladder urothelial carcinomas." in: Annals of diagnostic pathology, Vol. 16, Issue 5, pp. 362-8, (2012) (PubMed).

Uen, Tai, Shen, Lee, Tsao, Deng, Chiou, Hsu, Hsieh, Liao, Jiang: "Differential distributions of CSE1L/CAS and E-cadherin in the polarized and non-polarized epithelial glands of neoplastic colorectal epithelium." in: Journal of molecular histology, Vol. 41, Issue 4-5, pp. 259-66, (2010) (PubMed).

Stella Tsai, Chen, Tung, Tsou, Tsao, Liao, Chen, Yeh, Yeh, Jiang: "Serum cellular apoptosis susceptibility protein is a potential prognostic marker for metastatic colorectal cancer." in: The American journal of pathology, Vol. 176, Issue 4, pp. 1619-28, (2010) (PubMed).

Tsao, Tsai, Tung, Chen, Yue, Liao, Wang, Jiang: "Function of CSE1L/CAS in the secretion of HT-29 human colorectal cells and its expression in human colon." in: Molecular and cellular biochemistry, Vol. 327, Issue 1-2, pp. 163-70, (2009) (PubMed).

Tung, Tsai, Tung, Tsao, Chen, Yeh, Liao, Jiang: "Higher prevalence of secretory CSE1L/CAS in sera of patients with metastatic cancer." in: Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology, Vol. 18, Issue 5, pp. 1570-7, (2009) (PubMed).

Target Details for Exportin 2

Target: Exportin 2 (CSE1L) (CSE1 Chromosome Segregation 1-Like (CSE1L))

Alternative Name: CSE1L (CSE1L Products)

Synonyms: BcDNA:LD14270 antibody, CAS antibody, CG13281 antibody, Dcas antibody, Dmel\\CG13281 antibody, cas antibody, dcas antibody, l(2)k03902 antibody, CSE1L antibody, XPO2 antibody, Exportin-2 antibody, DKFZp459E1929 antibody, 2610100P18Rik antibody, AA407533 antibody, Capts antibody, Cas antibody, Xpo2 antibody, xpo2 antibody, CSE1 antibody, CAS/CSE1 segregation protein antibody, chromosome segregation 1 like antibody, exportin-2 antibody, chromosome segregation 1-like (S. cerevisiae) antibody, CSE1 chromosome segregation 1-like (yeast) antibody, CSE1 chromosome segregation 1-like L homeolog antibody, Cas antibody, CSE1L antibody, LOC100542094 antibody, cse1l antibody, Cse1l antibody, cse1l.L antibody

Background: Full Gene Name: CSE1 chromosome segregation 1-like (yeast)
Synonyms: CAS,CSE1,MGC117283,MGC130036,MGC130037,XPO2

Gene ID: 1434

NCBI Accession: NM_001316

Pathways: Protein targeting to Nucleus