CBS antibody (AA 1-551)

Catalog No. ABIN560204

Product Details anti-CBS Antibody

Target: CBS (Cystathionine-beta-Synthase (CBS))

Binding Specificity: AA 1-551

Reactivity: Human

Host: Mouse

Clonality: Polyclonal

Conjugate: This CBS antibody is un-conjugated

Application: Western Blotting (WB), ELISA

Purpose: Mouse polyclonal antibody raised against a full-length recombinant CBS.

Sequence: MPSETPQAEV GPTGCPHRSG PHSAKGSLEK GSPEDKEAKE PLWIRPDAPS RCTWQLGRPA SESPHHHTAP AKSPKILPDI LKKIGDTPMV RINKIGKKFG LKCELLAKCE FFNAGGSVKD RISLRMIEDA ERDGTLKPGD TIIEPTSGNT GIGLALAAAV RGYRCIIVMP EKMSSEKVDV LRALGAEIVR TPTNARFDSP ESHVGVAWRL KNEIPNSHIL DQYRNASNPL AHYDTTADEI LQQCDGKLDM LVASVGTGGT ITGIARKLKE KCPGCRIIGV DPEGSILAEP EELNQTEQTT YEVEGIGYDF IPTVLDRTVV DKWFKSNDEE AFTFARMLIA QEGLLCGGSA GSTVAVAVKA AQELQEGQRC VVILPDSVRN YMTKFLSDRW MLQKGFLKEE DLTEKKPWWW HLRVQELGLS APLTVLPTIT CGHTIEILRE KGFDQAPVVD EAGVILGMVT LGNMLSSLLA GKVQPSDQVG KVIYKQFKQI RLTDTLGRLS HILEMDHFAL VVHEQIQYHS TGKSSQRQMV FGVVTAIDLL NFVAAQERDQ K

Cross-Reactivity: Human

Characteristics: Antibody Reactive Against Recombinant Protein.

Immunogen: CBS (AAH11381.1, 1 a.a. ~ 551 a.a) full-length recombinant protein with GST tag.

Application Details

Application Notes: Optimal working dilution should be determined by the investigator.

Restrictions: For Research Use only

Handling

Format: Liquid

Buffer: 50 % glycerol

Handling Advice: Aliquot to avoid repeated freezing and thawing.

Storage: -20 °C

Storage Comment: Store at -20°C or lower. Aliquot to avoid repeated freezing and thawing.

References for anti-CBS antibody (ABIN560204)

Grassi, Tyagi, Calvert, Gambari, Walker, Yu, Robinson, Li, Lisignoli, Vaccaro, Adams, Pacifici: "Hydrogen Sulfide Is a Novel Regulator of Bone Formation Implicated in the Bone Loss Induced by Estrogen Deficiency." in: Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research, Vol. 31, Issue 5, pp. 949-63, (2016) (PubMed).

Martínez-Vega, Garrido, Partearroyo, Cediel, Zeisel, Martínez-Álvarez, Varela-Moreiras, Varela-Nieto, Pajares: "Folic acid deficiency induces premature hearing loss through mechanisms involving cochlear oxidative stress and impairment of homocysteine metabolism." in: FASEB journal : official publication of the Federation of American Societies for Experimental Biology, Vol. 29, Issue 2, pp. 418-32, (2015) (PubMed).

Kim, Lee, Lee, Park, Ryu: "Arsenite-induced changes in hepatic protein abundance in cynomolgus monkeys (Macaca fascicularis)." in: Proteomics, Vol. 14, Issue 15, pp. 1833-43, (2014) (PubMed).

Gupta, Wang, Anderl, Slifker, Kirk, Kruger: "Correction of cystathionine ?-synthase deficiency in mice by treatment with proteasome inhibitors." in: Human mutation, Vol. 34, Issue 8, pp. 1085-93, (2013) (PubMed).

Bhattacharyya, Saha, Giri, Lanza, Nair, Jennings, Rodriguez-Aguayo, Lopez-Berestein, Basal, Weaver, Visscher, Cliby, Sood, Bhattacharya, Mukherjee: "Cystathionine beta-synthase (CBS) contributes to advanced ovarian cancer progression and drug resistance." in: PLoS ONE, Vol. 8, Issue 11, pp. e79167, (2013) (PubMed).

Mayfield, Davies, Dimster-Denk, Pleskac, McCarthy, Boydston, Fink, Lin, Narain, Meighan, Rine: "Surrogate genetics and metabolic profiling for characterization of human disease alleles." in: Genetics, Vol. 190, Issue 4, pp. 1309-23, (2012) (PubMed).

Singh, Gupta, Honig, Kraus, Kruger: "Activation of mutant enzyme function in vivo by proteasome inhibitors and treatments that induce Hsp70." in: PLoS genetics, Vol. 6, Issue 1, pp. e1000807, (2010) (PubMed).

Wu, Siow, O: "Ischemia/reperfusion reduces transcription factor Sp1-mediated cystathionine beta-synthase expression in the kidney." in: The Journal of biological chemistry, Vol. 285, Issue 24, pp. 18225-33, (2010) (PubMed).

Singh, Kruger: "Functional rescue of mutant human cystathionine beta-synthase by manipulation of Hsp26 and Hsp70 levels in Saccharomyces cerevisiae." in: The Journal of biological chemistry, Vol. 284, Issue 7, pp. 4238-45, (2009) (PubMed).

dEmmanuele di Villa Bianca, Sorrentino, Maffia, Mirone, Imbimbo, Fusco, De Palma, Ignarro, Cirino: "Hydrogen sulfide as a mediator of human corpus cavernosum smooth-muscle relaxation." in: Proceedings of the National Academy of Sciences of the United States of America, Vol. 106, Issue 11, pp. 4513-8, (2009) (PubMed).

Ali, Whiteman, Low, Moore: "Hydrogen sulphide reduces insulin secretion from HIT-T15 cells by a KATP channel-dependent pathway." in: The Journal of endocrinology, Vol. 195, Issue 1, pp. 105-12, (2007) (PubMed).

Target Details for CBS

Target: CBS (Cystathionine-beta-Synthase (CBS))

Alternative Name: CBS (CBS Products)

Synonyms: hip4 antibody, GB12529 antibody, CBS antibody, DDBDRAFT_0189727 antibody, DDBDRAFT_0191292 antibody, DDB_0189727 antibody, DDB_0191292 antibody, cbs antibody, AI047524 antibody, AI303044 antibody, HIP4 antibody, cb442 antibody, wu:fb37g05 antibody, wu:fm61c07 antibody, wu:fq06c06 antibody, zgc:113704 antibody, cystathionine-beta-synthase L homeolog antibody, cystathionine-beta-synthase antibody, cystathionine beta-synthase antibody, cystathionine beta-synthase CBS antibody, cystathionine beta synthase antibody, cystathionine-beta-synthase S homeolog antibody, cystathionine-beta-synthase b antibody, cbs.L antibody, cbs antibody, Cbs antibody, CBS antibody, CNA06170 antibody, Tb11.02.5400 antibody, cysB antibody, LOC100635325 antibody, cbs.S antibody, cbsb antibody

Background: Full Gene Name: cystathionine-beta-synthase
Synonyms: HIP4

Gene ID: 875