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TET3 antibody (N-Term)

TET3 Reactivity: Human WB, ELISA Host: Rabbit Polyclonal unconjugated
Catalog No. ABIN5596980
  • Target See all TET3 Antibodies
    TET3 (Tet Methylcytosine Dioxygenase 3 (TET3))
    Binding Specificity
    • 6
    • 5
    • 4
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    N-Term
    Reactivity
    • 22
    • 7
    • 2
    Human
    Host
    • 13
    • 10
    • 1
    Rabbit
    Clonality
    • 15
    • 9
    Polyclonal
    Conjugate
    • 20
    • 2
    • 1
    • 1
    This TET3 antibody is un-conjugated
    Application
    • 18
    • 5
    • 5
    • 4
    • 4
    • 3
    • 2
    • 1
    • 1
    • 1
    • 1
    Western Blotting (WB), ELISA
    Cross-Reactivity (Details)
    It is directed against, and shows specific reactivity for Tet3 protein. Cross reactivity with Tet1 and Tet2 has not been determined.
    Purification
    Anti-TET3 Antibody was prepared from whole rabbit antiserum by delipidation and defibrination. The antiserum was further cross-absorbed against MBP by chromatography.
    Immunogen

    Immunogen: TET3 antibody was prepared from whole rabbit serum produced by repeated immunizations with a human TET-3 domain containing the N-terminal 160 amino acids of the protein.

    Immunogen Type: Recombinant Protein

    Top Product
    Discover our top product TET3 Primary Antibody
  • Application Notes

    Application Note: Tet3 antibody has been tested for use by ELISA and Western Blot. Specific conditions for reactivity should be optimized by the end user. Expect band at ~180 kDa.

    Western Blot Dilution: 1:5000

    ELISA Dilution: 1:50,000

    Restrictions
    For Research Use only
  • Format
    Liquid
    Concentration
    70 mg/mL
    Buffer

    Buffer: 0.02 M Potassium Phosphate, 0.15 M Sodium Chloride, pH 7.2

    Stabilizer: None

    Preservative
    Sodium azide
    Precaution of Use
    This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
    Storage
    4 °C,-20 °C
    Storage Comment
    Store vial at -20° C prior to opening. Aliquot contents and freeze at -20° C or below for extended storage. Avoid cycles of freezing and thawing. Centrifuge product if not completely clear after standing at room temperature. This product is stable for several weeks at 4° C as an undiluted liquid. Dilute only prior to immediate use.
    Expiry Date
    12 months
  • Target
    TET3 (Tet Methylcytosine Dioxygenase 3 (TET3))
    Alternative Name
    TET3 (TET3 Products)
    Synonyms
    B430006D22Rik antibody, BC037432 antibody, D230004J03Rik antibody, tet methylcytosine dioxygenase 3 antibody, Tet3 antibody, TET3 antibody
    Background

    Synonyms: TET antibodies, Anti-TET Methylcytosine Dioxygenase 3, Anti-TET3 polyclonal antibody, KIAA0401 antibody, dioxygenase antibodies

    Background: Anti-Tet3 is expressed in colon, muscle, adrenal gland and peripheral blood lymphocytes. Anti-Tet3 is involved in the epigenetic chromatin reprogramming of a zygote after its fertilization, and the demethylation occurs before the first cell division in the paternal pronucleus. Tet 3 antibody cannot bind to the maternal pronucleus chromatin due to DPPA3/PGC7 chromatin presence. Tet 3 functions as the dioxygenase which synthesizes a hydroxyl group to 5-methylcystosine (5mC) to form 5-hydroxymethylcystosine. Tet3 mediates the formation of 5-formylcystosine from 5hmC and subsequently 5fC to 5-carboxylcystosine, and consequently Tet3 plays an active role in catalyzing those conversions which have been suggested as the first step for cytosine DNA de-methylation. Tet 3 also recruits O-GlcNAc transferase OGT to aid H2B GlcNAcylation by OGT. Anti-TET3 antibodies are ideal for researchers interested in Epigenetics, Cancer, Chromatin Research and Histone research.

    Gene ID
    200424
    UniProt
    O43151
    Pathways
    Warburg Effect
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