C19ORF80 antibody

Catalog No. ABIN5564288

Product Details anti-C19ORF80 Antibody

Target: C19ORF80 (Chromosome 19 Open Reading Frame 80 (C19ORF80))

Reactivity: Human

Host: Rabbit

Clonality: Polyclonal

Conjugate: This C19ORF80 antibody is un-conjugated

Application: ELISA, Western Blotting (WB)

Specificity: Recognizes human betatrophin.

Cross-Reactivity: Human

Immunogen: Recombinant human betatrophin.

Application Details

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: Lot specific

Buffer: In PBS containing 10 % glycerol and 0.02 % sodium azide.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: 4 °C,-20 °C

Storage Comment: Short Term Storage: +4°C
Long Term Storage: -20°C
Stable for at least 1 year after receipt when stored at -20°C.

Expiry Date: 12 months

References for anti-C19ORF80 antibody (ABIN5564288)

Sun, Liu, Li, Tang, Zou, Chen, Zheng, Jiang, Shi: "Transplantation of betatrophin-expressing adipose-derived mesenchymal stem cells induces β-cell proliferation in diabetic mice." in: International journal of molecular medicine, Vol. 39, Issue 4, pp. 936-948, (2017) (PubMed).

Target Details for C19ORF80

Target: C19ORF80 (Chromosome 19 Open Reading Frame 80 (C19ORF80))

Alternative Name: Betatrophin (C19ORF80 Products)

Synonyms: ANGPTL8 antibody, PRO1185 antibody, PVPA599 antibody, RIFL antibody, TD26 antibody, angiopoietin like 8 antibody, ANGPTL8 antibody

Background: Betatrophin (RIFL, Lipasin, Angiopoietin-like protein 8 (ANGPTL8)) is a newly discovered secreted protein of 198 aa that was proposed to promote beta cell proliferation and improve glucose tolerance in mice. Betatrophin may also function in inhibition of lipase activity and on serum triglyceride regulation. Betatrophin is expressed in the liver and in white and brown adipose tissue of mice. In humans, betatrophin is found to be predominantly expressed in the liver. Betatrophin levels are reduced by fasting and are elevated upon insulin resistance and during pregnancy. Betatrophin, according to preliminary data could bind to the macrophage receptor Marco and also to RTN4R, a neuronal receptor. Recently, a study using ANGPTL8 KO mice showed that ANGPTL8/Betatrophin does not play a role in beta cell proliferation nor in glycemic control as previously thought, but regulates plasma triglyceride levels.