IL1F10 antibody

Catalog No. ABIN5564279

Product Details anti-IL1F10 Antibody

Target: IL1F10 (Interleukin 1 Family, Member 10 (Theta) (IL1F10))

Reactivity: Human, Mouse

Host: Mouse

Clonality: Monoclonal

Conjugate: This IL1F10 antibody is un-conjugated

Application: ELISA, Western Blotting (WB)

Specificity: Recognizes human and mouse IL-38.

Cross-Reactivity: Human, Mouse (Murine)

Purity: >95 % (SDS-PAGE)

Immunogen: Recombinant human IL-38.

Clone: Nhat-1

Isotype: IgG2b

Application Details

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: Lot specific

Buffer: In PBS containing 10 % glycerol and 0.02 % sodium azide.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: 4 °C,-20 °C

Storage Comment: Short Term Storage: +4°C
Long Term Storage: -20°C
Stable for at least 1 year after receipt when stored at -20°C.

Expiry Date: 12 months

Target Details for IL1F10

Target: IL1F10 (Interleukin 1 Family, Member 10 (Theta) (IL1F10))

Alternative Name: IL-38 (IL1F10 Products)

Synonyms: FIL1-theta antibody, IL-1HY2 antibody, IL-38 antibody, IL1-theta antibody, IL1HY2 antibody, interleukin 1 family, member 10 antibody, interleukin 1 family member 10 antibody, Il1f10 antibody, IL1F10 antibody

Background: IL-38 (IL-1F10) belongs to the IL-1 family of proteins. IL-38 is expressed in heart, placenta, fetal liver, spleen, thymus and tonsil. The expression in a variety of immune tissues and similarity to IL-1Ra suggest a role of IL-38 as a IL-1 family receptor antagonist. Il-38 inhibits IL-36 signaling by binding to IL-1R6. IL-38 (aa 20-152) is released from apoptotic cells to limit inflammatory macrophage and downstream Th17 activation by blocking IL1RAPL1 (Interleukin-1 receptor accessory protein-like 1, TIGIRR-2) signaling. IL-38 is unregulated during some autoimmune diseases such as Systemic Lupus Erythematosus.