Recombinant CD40L (Ruplizumab Biosimilar) antibody
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- Target See all CD40L (Ruplizumab Biosimilar) products
- CD40L (Ruplizumab Biosimilar)
- Antibody Type
- Recombinant Antibody
- Reactivity
- Human, Dog
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Host
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Human
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Clonality
- Monoclonal
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Conjugate
- This CD40L (Ruplizumab Biosimilar) antibody is un-conjugated
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Application
- Flow Cytometry (FACS), Western Blotting (WB), Functional Studies (Func)
- Specificity
- Recognizes and binds human CD40L with an IC50 of 0.845 μg/mL.
- Cross-Reactivity
- Dog (Canine), Human
- Cross-Reactivity (Details)
- Cross-reacts with canine CD40L.
- Purity
- >95 % (SDS-PAGE)
- Endotoxin Level
- <0.001EU/μg
- Immunogen
- Recombinant human CD40L.
- Clone
- Hu5c8
- Isotype
- IgG1
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- Comment
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This antibody is a biosimilar called Ruplizumab (Antova, BG9588) and originally developed by Biogen. Ruplizumab is a CD40 ligand blocker designed for the treatment of rheumatic diseases like systemic lupus erythematosus and lupus nephritis, but withdrawn from clinical trials due to side effects.
- Restrictions
- For Research Use only
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- Format
- Liquid
- Concentration
- Lot specific
- Buffer
- In PBS.
- Preservative
- Without preservative
- Storage
- 4 °C,-20 °C
- Storage Comment
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Short Term Storage: +4°C
Long Term Storage: -20°C
Stable for at least 1 year after receipt when stored at -20°C. Stable for at least 3 months after receipt when stored at +4°C. - Expiry Date
- 12 months
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- Target
- CD40L (Ruplizumab Biosimilar)
- Abstract
- CD40L (Ruplizumab Biosimilar) Products
- Synonyms
- CD154 antibody, CD40L antibody, HIGM1 antibody, IGM antibody, IMD3 antibody, T-BAM antibody, TNFSF5 antibody, TRAP antibody, gp39 antibody, hCD40L antibody, CD40 ligand antibody, CD40LG antibody
- Target Type
- Biosimilar
- Background
- CD40 Ligand (CD40L), renamed TNFSF5 but now also known as CD154, TRAP and gp39, is a 34-39 kDa type II transmembrane glycoprotein, that belongs to the TNF superfamily, and a surface receptor expressed on activated T cells which acts as a costimulatory molecule to trigger immune responses. CD40L binds to CD40, which is essential in mediating a broad variety of immune and inflammatory responses including T cell-dependent immunoglobulin class switching, memory B cell development and germinal center formation. CD40 is constitutively expressed by antigen presenting cells, including dendritic cells, B cells and macrophages. Consistent with its widespread expression on normal cells, CD40 is also expressed on a wide range of tumor cells. CD40L levels are increased in serum and in inflamed tissues of patients with autoimmune diseases.
- UniProt
- P29965
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