SEC31A antibody (AA 429-571)

Catalog No. ABIN5542690

Product Details anti-SEC31A Antibody

Target: SEC31A (SEC31 Homolog A (SEC31A))

Binding Specificity: AA 429-571

Reactivity: Human

Host: Mouse

Clonality: Monoclonal

Conjugate: This SEC31A antibody is un-conjugated

Application: ELISA, Immunohistochemistry (IHC)

Purpose: SEC31A Antibody

Purification: Purified antibody

Immunogen: Purified recombinant fragment of human SEC31A (AA: 429-571) expressed in E. Coli.

Clone: 5D12C6

Isotype: IgG1

Application Details

Application Notes: ELISA: 1/10000

Restrictions: For Research Use only

Handling

Format: Liquid

Buffer: Purified antibody in PBS with 0.05 % sodium azide.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: 4 °C,-20 °C

Storage Comment: Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles.

Target Details for SEC31A

Target: SEC31A (SEC31 Homolog A (SEC31A))

Alternative Name: SEC31A (SEC31A Products)

Background:

Description: The protein encoded by this gene shares similarity with the yeast Sec31 protein, and is a component of the outer layer of the coat protein complex II (COPII). The encoded protein is involved in vesicle budding from the endoplasmic reticulum (ER) and contains multiple WD repeats near the N-terminus and a proline-rich region in the C-terminal half. It associates with the protein encoded by the SEC13 homolog, nuclear pore and COPII coat complex component (SEC13), and is required for ER-Golgi transport. Monoubiquitylation of this protein by CUL3-KLHL12 was found to regulate the size of COPII coats to accommodate unusually shaped cargo. Alternative splicing results in multiple transcript variants encoding different isoforms.

Aliases: ABP125, ABP130, HSPC275, HSPC334, SEC31L1

Molecular Weight: 133kDa

Gene ID: 22872

HGNC: 22872

UniProt: O94979

Pathways: ER-Nucleus Signaling