MMP14 antibody (AA 112-246)

Catalog No. ABIN5542659

Product Details anti-MMP14 Antibody

Target: MMP14 (Matrix Metallopeptidase 14 (Membrane-inserted) (MMP14))

Binding Specificity: AA 112-246

Reactivity: Human

Host: Mouse

Clonality: Monoclonal

Conjugate: This MMP14 antibody is un-conjugated

Application: ELISA, Immunohistochemistry (IHC), Flow Cytometry (FACS)

Purpose: MMP14 Antibody

Purification: Purified antibody

Immunogen: Purified recombinant fragment of human MMP14 (AA: 112-246) expressed in E. Coli.

Clone: 6A11D1

Isotype: IgG1

Application Details

Application Notes:

ELISA: 1/10000

FCM: 1/200 - 1/400

Restrictions: For Research Use only

Handling

Format: Liquid

Buffer: Purified antibody in PBS with 0.05 % sodium azide.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: 4 °C,-20 °C

Storage Comment: Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles.

Target Details for MMP14

Target: MMP14 (Matrix Metallopeptidase 14 (Membrane-inserted) (MMP14))

Alternative Name: MMP14 (MMP14 Products)

Background:

Description: Proteins of the matrix metalloproteinase (MMP) family are involved in the breakdown of extracellular matrix in normal physiological processes, such as embryonic development, reproduction, and tissue remodeling, as well as in disease processes, such as arthritis and metastasis. Most MMP's are secreted as inactive proproteins which are activated when cleaved by extracellular proteinases. However, the protein encoded by this gene is a member of the membrane-type MMP (MT-MMP) subfamily, each member of this subfamily contains a potential transmembrane domain suggesting that these proteins are expressed at the cell surface rather than secreted. This protein activates MMP2 protein, and this activity may be involved in tumor invasion.

Aliases: MMP-14, MMP-X1, MT-MMP, MT1MMP, MTMMP1, WNCHRS, MT1-MMP, MT-MMP 1

Molecular Weight: 65.9kDa

Gene ID: 4323

HGNC: 4323

UniProt: P50281

Pathways: Autophagy