CFHR5 antibody (AA 344-569)

Catalog No. ABIN5542639

Product Details anti-CFHR5 Antibody

Target: CFHR5 (Complement Factor H-Related 5 (CFHR5))

Binding Specificity: AA 344-569

Reactivity: Human

Host: Mouse

Clonality: Monoclonal

Conjugate: This CFHR5 antibody is un-conjugated

Application: ELISA, Flow Cytometry (FACS), Immunohistochemistry (IHC), Immunocytochemistry (ICC)

Purpose: CFHR5 Antibody

Purification: Purified antibody

Immunogen: Purified recombinant fragment of human CFHR5 (AA: 344-569) expressed in E. Coli.

Clone: 3E1E10

Isotype: IgG1

Application Details

Application Notes:

ELISA: 1/10000

FCM: 1/200 - 1/400

ICC: 1/200 - 1/1000

Restrictions: For Research Use only

Handling

Format: Liquid

Buffer: Purified antibody in PBS with 0.05 % sodium azide.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: 4 °C,-20 °C

Storage Comment: Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles.

Target Details for CFHR5

Target: CFHR5 (Complement Factor H-Related 5 (CFHR5))

Alternative Name: CFHR5 (CFHR5 Products)

Synonyms: CFHL5 antibody, CFHR5D antibody, FHR-5 antibody, FHR5 antibody, complement factor H related 5 antibody, CFHR5 antibody

Background:

Description: This gene is a member of a small complement factor H (CFH) gene cluster on chromosome 1. Each member of this gene family contains multiple short consensus repeats (SCRs) typical of regulators of complement activation. The protein encoded by this gene has nine SCRs with the first two repeats having heparin binding properties, a region within repeats 5-7 having heparin binding and C reactive protein binding properties, and the C-terminal repeats being similar to a complement component 3 b (C3b) binding domain. This protein co-localizes with C3, binds C3b in a dose-dependent manner, and is recruited to tissues damaged by C-reactive protein. Allelic variations in this gene have been associated, but not causally linked, with two different forms of kidney disease: membranoproliferative glomerulonephritis type II (MPGNII) and hemolytic uraemic syndrome (HUS).

Aliases: FHR5, CFHL5, FHR-5, CFHR5D

Molecular Weight: 64.4kDa

Gene ID: 81494

HGNC: 81494

UniProt: Q9BXR6