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HLA-DRA antibody (AA 26-254)

HLA-DRA Reactivity: Human WB, IHC, FACS, ELISA, ICC Host: Mouse Monoclonal 1C11A5 unconjugated
Catalog No. ABIN5542623
  • Target See all HLA-DRA Antibodies
    HLA-DRA (HLA Class II DR alpha (HLA-DRA))
    Binding Specificity
    • 8
    • 5
    • 4
    • 3
    • 3
    • 2
    • 2
    • 2
    • 2
    • 2
    • 1
    • 1
    AA 26-254
    Reactivity
    • 85
    • 17
    • 10
    • 10
    • 9
    • 9
    • 3
    • 2
    • 2
    • 1
    Human
    Host
    • 57
    • 42
    • 2
    • 1
    Mouse
    Clonality
    • 59
    • 43
    Monoclonal
    Conjugate
    • 49
    • 12
    • 5
    • 3
    • 3
    • 3
    • 3
    • 3
    • 3
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 1
    • 1
    This HLA-DRA antibody is un-conjugated
    Application
    • 45
    • 43
    • 34
    • 30
    • 15
    • 10
    • 10
    • 9
    • 9
    • 3
    • 3
    • 3
    • 1
    • 1
    • 1
    Western Blotting (WB), Immunohistochemistry (IHC), Flow Cytometry (FACS), ELISA, Immunocytochemistry (ICC)
    Purification
    purified
    Immunogen
    Purified recombinant fragment of human HLA-DRA (AA: 26-254) expressed in E. coli.
    Clone
    1C11A5
    Isotype
    IgG2b
  • Application Notes
    ELISA: 1:10000, WB: 1:500 - 1:2000, IHC: , ICC: 1:100 - 1:500, FCM: 1:200 - 1:400
    Restrictions
    For Research Use only
  • Format
    Liquid
    Buffer
    Purified antibody in PBS with 0.05 % sodium azide
    Preservative
    Sodium azide
    Precaution of Use
    This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
    Storage
    4 °C/-20 °C
    Storage Comment
    4°C, -20°C for long term storage
  • Target
    HLA-DRA (HLA Class II DR alpha (HLA-DRA))
    Alternative Name
    HLA-DRA (HLA-DRA Products)
    Synonyms
    HLA-DRA1 antibody, MLRW antibody, DR-alpha antibody, HLA-DRA antibody, Mamu-DRA1 antibody, major histocompatibility complex, class II, DR alpha L homeolog antibody, major histocompatibility complex, class II, DR alpha antibody, hla-dra.L antibody, HLA-DRA antibody, MAMU-DRA antibody, BOLA-DRA antibody
    Background

    Description: HLA-DRA is one of the HLA class II alpha chain paralogues. This class II molecule is a heterodimer consisting of an alpha and a beta chain, both anchored in the membrane. It plays a central role in the immune system by presenting peptides derived from extracellular proteins. Class II molecules are expressed in antigen presenting cells (APC: B lymphocytes, dendritic cells, macrophages). The alpha chain is approximately 33-35 kDa and its gene contains 5 exons. Exon 1 encodes the leader peptide, exons 2 and 3 encode the two extracellular domains, and exon 4 encodes the transmembrane domain and the cytoplasmic tail. DRA does not have polymorphisms in the peptide binding part and acts as the sole alpha chain for DRB1, DRB3, DRB4 and DRB5. ,

    Aliases: MLRW, HLA-DRA1

    Molecular Weight
    28.6 kDa
    Gene ID
    3122
    HGNC
    3858
    Pathways
    TCR Signaling, CXCR4-mediated Signaling Events, Human Leukocyte Antigen (HLA) in Adaptive Immune Response
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