PMS2 antibody (AA 748-851)

Catalog No. ABIN5542596

Product Details anti-PMS2 Antibody

Target: PMS2 (PMS2 Postmeiotic Segregation Increased 2 (S. Cerevisiae) (PMS2))

Binding Specificity: AA 748-851

Reactivity: Human

Host: Mouse

Clonality: Monoclonal

Conjugate: This PMS2 antibody is un-conjugated

Application: ELISA, Immunocytochemistry (ICC), Flow Cytometry (FACS)

Purpose: PMS2 Antibody

Purification: Purified antibody

Immunogen: Purified recombinant fragment of human PMS2 (AA: 748-851) expressed in E. Coli.

Clone: 1E9D11

Isotype: IgG1

Application Details

Application Notes:

ELISA: 1/10000

FCM: 1/200 - 1/400

ICC: 1/200 - 1/1000

Restrictions: For Research Use only

Handling

Format: Liquid

Buffer: Purified antibody in PBS with 0.05 % sodium azide.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: 4 °C,-20 °C

Storage Comment: Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles.

Target Details for PMS2

Target: PMS2 (PMS2 Postmeiotic Segregation Increased 2 (S. Cerevisiae) (PMS2))

Alternative Name: PMS2 (PMS2 Products)

Background:

Description: This gene is one of the PMS2 gene family members found in clusters on chromosome 7. The product of this gene is involved in DNA mismatch repair. It forms a heterodimer with MLH1 and this complex interacts with other complexes bound to mismatched bases. Mutations in this gene are associated with hereditary nonpolyposis colorectal cancer, Turcot syndrome, and are a cause of supratentorial primitive neuroectodermal tumors. Alternatively spliced transcript variants have been observed for this gene.

Aliases: PMSL2, HNPCC4, PMS2CL

Molecular Weight: 95.8kDa

Gene ID: 5395

HGNC: 5395

UniProt: P54278

Pathways: DNA Damage Repair, Production of Molecular Mediator of Immune Response