ATG5 antibody

Catalog No. ABIN5542579

Product Details anti-ATG5 Antibody

Target: ATG5 (ATG5 Autophagy Related 5 (ATG5))

Reactivity: Human

Host: Mouse

Clonality: Monoclonal

Conjugate: This ATG5 antibody is un-conjugated

Application: Western Blotting (WB), ELISA, Flow Cytometry (FACS), Immunocytochemistry (ICC)

Purpose: ATG5 Antibody

Sequence: Synthesize d peptide of human ATG5 (AA: MTDDKDVLRD VWFGRIc).

Purification: Purified antibody

Immunogen: Synthesized peptide of human ATG5 (AA: MTDDKDVLRDVWFGRIc).

Clone: 8E8G6

Isotype: IgG2a

Application Details

Application Notes:

ELISA: 1/10000

FCM: 1/200 - 1/400

ICC: 1/200 - 1/1000

Restrictions: For Research Use only

Handling

Format: Liquid

Buffer: Purified antibody in PBS with 0.05 % sodium azide.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: 4 °C,-20 °C

Storage Comment: Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles.

Target Details for ATG5

Target: ATG5 (ATG5 Autophagy Related 5 (ATG5))

Alternative Name: ATG5 (ATG5 Products)

Synonyms: APG5 antibody, APG5-LIKE antibody, APG5L antibody, ASP antibody, hAPG5 antibody, ATG5 antibody, CG1643 antibody, DmAtg5 antibody, Dmel\\CG1643 antibody, atg5 antibody, 2010107M05Rik antibody, 3110067M24Rik antibody, AW319544 antibody, Apg5l antibody, Atg5l antibody, C88337 antibody, Paddy antibody, apg5l antibody, zgc:100934 antibody, ATATG5 antibody, AUTOPHAGY 5 antibody, MKP11.20 antibody, MKP11_20 antibody, autophagy related 5 antibody, Autophagy-related 5 antibody, ATG5 autophagy related 5 homolog (S. cerevisiae) antibody, autophagy related 5 L homeolog antibody, similar to S. cerevisiae ATG5 (YPL149W) which nucleates preautophagosome formation as a conjugate with Atg12 antibody, autophagy protein Apg5 family antibody, ATG5 antibody, Atg5 antibody, atg5 antibody, atg5.L antibody, APG5 antibody

Background:

Description: ATG5 involved in autophagic vesicle formation. Conjugation with ATG12, through a ubiquitin-like conjugating
system involving ATG7 as an E1-like activating enzyme and ATG10 as an E2-like conjugating enzyme, is essential
for its function. The ATG12-ATG5 conjugate acts as an E3-like enzyme which is required for lipidation of ATG8
family proteins and their association to the vesicle membranes. Involved in mitochondrial quality control after
oxidative damage, and in subsequent cellular longevity. The ATG12-ATG5 conjugate also negatively regulates the
innate antiviral immune response by blocking the type I IFN production pathway through direct association with
RARRES3 and MAVS. Also plays a role in translation or delivery of incoming viral RNA to the translation
apparatus. Plays a critical role in multiple aspects of lymphocyte development and is essential for both B and T
lymphocyte survival and proliferation. Required for optimal processing and presentation of antigens for MHC II.
Involved in the maintenance of axon morphology and membrane structures, as well as in normal adipocyte
differentiation. Promotes primary ciliogenesis through removal of OFD1 from centriolar satellites and degradation
of IFT20 via the autophagic pathway

Aliases: ASP, APG5, APG5L, hAPG5, APG5-LIKE

Molecular Weight: 32.4kDa

Gene ID: 9474

HGNC: 9474

UniProt: Q9H1Y0

Pathways: Activation of Innate immune Response, Production of Molecular Mediator of Immune Response, Autophagy