UHRF1 antibody (AA 616-755)
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- Target See all UHRF1 Antibodies
- UHRF1 (Ubiquitin-Like, Containing PHD and RING Finger Domains, 1 (UHRF1))
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Binding Specificity
- AA 616-755
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Reactivity
- Human
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Host
- Mouse
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Clonality
- Monoclonal
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Conjugate
- This UHRF1 antibody is un-conjugated
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Application
- Western Blotting (WB), ELISA, Immunohistochemistry (IHC), Immunocytochemistry (ICC), Flow Cytometry (FACS)
- Purification
- purified
- Immunogen
- Purified recombinant fragment of human UHRF1 (AA: 616-755) expressed in E. coli.
- Clone
- 1A1B1
- Isotype
- IgG2b
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- Application Notes
- ELISA: 1:10000, WB: 1:500 - 1:2000, IHC: 1:200 - 1:1000, ICC: 1:200 - 1:1000, FCM: 1:200 - 1:400
- Restrictions
- For Research Use only
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- Format
- Liquid
- Buffer
- Purified antibody in PBS with 0.05 % sodium azide
- Preservative
- Sodium azide
- Precaution of Use
- This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
- Storage
- 4 °C/-20 °C
- Storage Comment
- 4°C, -20°C for long term storage
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- Target
- UHRF1 (Ubiquitin-Like, Containing PHD and RING Finger Domains, 1 (UHRF1))
- Alternative Name
- UHRF1 (UHRF1 Products)
- Synonyms
- ICBP90 antibody, Np95 antibody, RNF106 antibody, hNP95 antibody, hUHRF1 antibody, AL022808 antibody, NP95 antibody, fb97f09 antibody, wu:fb97f09 antibody, zgc:63539 antibody, UHRF1 antibody, ubiquitin like with PHD and ring finger domains 1 antibody, ubiquitin-like, containing PHD and RING finger domains, 1 antibody, ubiquitin-like with PHD and ring finger domains 1 antibody, UHRF1 antibody, Uhrf1 antibody, uhrf1 antibody
- Background
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Description: This gene encodes a member of a subfamily of RING-finger type E3 ubiquitin ligases. The protein binds to specific DNA sequences, and recruits a histone deacetylase to regulate gene expression. Its expression peaks at late G1 phase and continues during G2 and M phases of the cell cycle. It plays a major role in the G1/S transition by regulating topoisomerase IIalpha and retinoblastoma gene expression, and functions in the p53-dependent DNA damage checkpoint. It is regarded as a hub protein for the integration of epigenetic information. This gene is up-regulated in various cancers, and it is therefore considered to be a therapeutic target. Multiple transcript variants encoding different isoforms have been found for this gene. A related pseudogene exists on chromosome 12.,
Aliases: Np95, hNP95, ICBP90, RNF106, TDRD22, hUHRF1, huNp95
- Molecular Weight
- 89.8 kDa
- Gene ID
- 29128
- HGNC
- 84632
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